Publication: Clinical applications of detecting dysfunctional p53 tumor suppressor protein
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Date
1999
Authors
Baas, I.O. ; Hruban, R.H. ; Offerhaus, G.J.A.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The p53 gene encodes for a protein, p53,
which plays a critical role in controlling the cell cycle, in
DNA repair and in programed cell death (apoptosis). p53
is one of the most frequently mutated genes in human
neoplasms and a variety of techniques have been
developed to detect these mutations. These range from
advanced molecular-genetic analyses to immunohistochemical
staining for the p53 protein. This review
will summarize our current understanding of the
function of p53 as well as current methods to detect
dysfunctional p53 and the clinical value of such
analyses.
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Citation
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