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Fe-LMCT photodecarboxylation for (hetero)arene chloro- and bromodifluoromethylation: rapid access to aromatic acyl fluorides

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dc.contributor.authorJuliá Hernández, Francisco
dc.contributor.authorFernández-García, Sara
dc.contributor.authorVisiedo-Jiménez, Paula
dc.contributor.departmentQuímica Inorgánica
dc.contributor.otherFacultad de Química
dc.date.accessioned2026-09-02T11:11:06Z
dc.date.available2026-09-02T11:11:06Z
dc.date.copyright©2026 The Authors
dc.date.issued2026-04-20
dc.description.abstractChloro- and bromodifluoromethyl groups (CF2X) offer complementary properties to other fluorinated substituents in modulating biological functionality and provide versatile synthetic handles for postfunctionalization. However, their widespread use remains limited by the scarcity of practical halodifluoromethylating reagents. Here, we report a photoinduced Fe-catalyzed strategy that repurposes readily available chloro- and bromodifluoroacetates as traceless radical precursors for (hetero)arene C–H halodifluoroalkylations. The resulting products exhibit broad synthetic versatility, enabling streamlined one-pot access to valuable acyl fluoride synthons.
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dc.format.extent6
dc.identifier.citationOrg. Lett. 2026, 28, 5574-5579
dc.identifier.doihttps://doi.org/10.1021/acs.orglett.6c01214
dc.identifier.issn1523-7060
dc.identifier.urihttps://hdl.handle.net/10201/247981
dc.languageeng
dc.publisherAmerican Chemical Society
dc.relationfinancial support provided by grant PID2023-151452NB-I00 to F.J.-H. funded by MICIU/AEI/10.13039/501100011033, by “ERDF A way of making Europe” and by the “European Union”. We also thank funding by MICIU/AEI/10.13039/501100011033, by “ERDF A way of making Europe”, by the “European Union” and by “European Union NextGenerationEU/PRTR” (CNS2023-145163, PID2020-115408GA-I00 and RYC2018-024643-I to F.J.-H.; and PRE2021-099616 to S.F.-G.). Fundación Séneca Región de Murcia (22510/PI/24 to F.J.-H.; and 22795/FPI/24 to P.V.-J.) is also acknowledged. We also thank Universidad de Murcia (ATTRACT-RYC) and the research support area ACTI that helped with the characterization of the compounds.
dc.relation.publisherversionhttps://pubs.acs.org/orlef7/article/28/17/5574/5141396/Fe-LMCT-Photodecarboxylation-for-Hetero-arene
dc.relation.requireshttps://doi.org/10.1021/acs.orglett.6c01214
dc.rightsAttribution 4.0 International*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectSynthetic methodology
dc.subjectPhotocatalysis
dc.subject.odsNo relacionado con ningún objetivo de desarrollo sostenible
dc.titleFe-LMCT photodecarboxylation for (hetero)arene chloro- and bromodifluoromethylation: rapid access to aromatic acyl fluorides
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersión
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relation.isAuthorOfPublication6131f4c4-1b4e-474a-ab7a-7a4b978410a0
relation.isAuthorOfPublication.latestForDiscovery6131f4c4-1b4e-474a-ab7a-7a4b978410a0
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