Publication: Tumor suppression by p53, making cells senescent
Authors
Qian, Yingjuan ; Chen, X.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Cellular senescence is a permanent cell cycle
arrest and a potent tumor suppression mechanism. The
p53 tumor suppressor is a sequence-specific
transcription factor and acts as a central hub sensing
various stress signals and activating an array of target
genes to induce cell cycle arrest, apoptosis, and
senescence. Recent reports showed that restoration of
p53 induces premature senescence and tumor regression
in mice with hepatocarcinomas or sarcomas. Thus, p53-
mediated senescence is capable of eliminating cancer
cells in vivo. p63 and p73, two homologues of p53, have
similar function in cell cycle arrest and apoptosis.
However, the role of p63 and p73 in cellular senescence
is elusive. In this review, we will discuss how p53
regulates senescence and future studies about p53 family
members in senescence.
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Citation
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