Publication: Ischemia-reperfusion of human skeletal muscle during aortoiliac surgery: effects of acetylcarnitine
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Date
1994
Authors
Adembri, C. ; Lombardo Domenici, L. ; Formigli, L. ; Brunelleschi, S. ; Ferrari, E. ; Novelli, G.P.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Our previous study on human skeletal
muscle undergoing ischemia and reperfusion has
revealed that granulocytes, which infiltrate the muscle
tissue in large numbers, play an important role in
mediating fibre injuries by producing superoxide anion
(O?) which is responsible for membrane lipid
peroxidation. In the current study, five patients
undergoing aortic reconstructive surgery were given
acetyl-carnitine (2 mglkg i.v. plus 1 mglkglmin for 30
min) prior to the induction of ischemia. Muscle biopsies
and blood samples were examined: a) after anaesthesia;
b) at the end of ischemia; and c) 30 min after
reperfusion, with the aim of elucidating whether acetylcarnitine
could prevent the infiltration andlor the
activation of granulocytes and eventually skeletal
muscle injuries. During ischemia and reperfusion
complement activation recmited numerous granulocytes
into the muscle tissue, but, contrary to the untreated
samples, the ability for O2 -generation of these cells
remained at low levels and was comparable to that of
ischemia even when molecular 02 was reintroduced to
the tissue. Accordingly, the morphological changes of
the postischemic muscle fibers were substantially
reduced when compared to the untreated samples; in fact, the mitochondrial swelling was only moderate and
the intramitochondrial dense bodies were small and
scarce. The current findings support a positive role of
acetyl-carnitine in ameliorating the ischernia-reperfusion
(1-R)-induced damage of human skeletal muscle.
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