Publication:
Critical role of von Willebrand factor and platelet interaction in venous thromboembolism

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dc.contributor.authorTakahashi, Misakies
dc.contributor.authorYamashita, Atsushies
dc.contributor.authorMoriguchi-Goto, Sayaka
dc.contributor.authorMarutsuka, Kousuke
dc.contributor.authorSato, Yuichiro
dc.contributor.authorYamamoto, Hiroshi
dc.contributor.authorKoshimoto, Chihiro
dc.contributor.authorAsada, Yujiro
dc.date.accessioned2014-01-09T10:37:29Z
dc.date.available2014-01-09T10:37:29Z
dc.date.issued2009
dc.description.abstractIt has been generally considered that platelets are less important in venous thrombus formation. However, clinical studies have shown an association between venous thromboembolism (VTE) and von Willebrand factor (VWF). We therefore investigated the contribution of VWF and platelet interaction to the onset of VTE using tissues from autopsies and from an animal model. An immunohistochemical study revealed that glycoprotein (GP) IIb/IIIa, fibrin, glycophorin A (erythrocyte-specific protein) and VWF were consistently localized in ilio-femoral venous thrombi and in pulmonary thromboemboli from 8 autopsied cases who died of VTE, and VWF was closely associated with GPIIb/IIIa and fibrin. Venous thrombi and pulmonary emboli contained significant amounts of GPIIb/IIIa and VWF, in addition to glycophorin A and fibrin, and the factors did not significantly differ between them. A rabbit model of VTE was developed by inserting a polyethylene tube into the iliac vein. The constituents of the induced thrombi were quite similar to those of human VTE. An antibody against VWF (AJW200), which inhibits interactions between the VWF A1 domain and platelet GPIb, significantly reduced venous thrombus formation and pulmonary thromboembolism in the model. These results suggest that VWF A1-platelet GPIb interaction plays a significant role in venous thrombus formation.es
dc.formatapplication/pdfes
dc.format.extent8es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/37544
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectVenous thromboembolismes
dc.subjectPlateletes
dc.subject.other616.1 - Patología del sistema circulatorio, de los vasos sanguíneos. Transtornos cardiovasculareses
dc.titleCritical role of von Willebrand factor and platelet interaction in venous thromboembolismes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.24,nº11 (2009)