Publication: BCL10 expression and localization in
Ocular Adnexa MALT lymphomas: a comparative
cytogenetic and immunohistochemical study
Authors
Cerrone, Margherita ; Collina, Francesca ; De Chiara, Anna ; Corazzelli, Gaetano ; Curcio, Maria Pia ; De Renzo, Amalia ; Russo, Filippo ; Cantile, Monica ; Staibano, Stefania ; Strianese, Diego ; Tranfa, Fausto ; Botti, Gerardo ; De Rosa, Gaetano ; Franco, Renato
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Summary. T(1;14) (p22;q32) involving BCL10 and IGH
genes is a rare but recurrent chromosomal aberration in
MALT-type lymphoma. It is rarely described in ocular
adnexa B cell lymphomas, although nuclear BCL10
shuttling seems to be critical for disease progression in
this district. We have evaluated the translocations MALT
lymphoma-related in a series of 45 ocular adnexa cases,
focusing in particular on their relation with BCL10
expression and its cellular topographic distribution. A
prognostic tissue microarray (TMA) with ocular adnexa
MALT lymphomas was designed. A study of BCL10
expression and its topographic distribution was
performed through immunohistochemistry. In addition
the assessment of t(14;18) (q32;q21), t(1;14) (p22;q32)
and t(11;18) (q21;q21) was determined by Fluorescent In
Situ Hybridization (FISH).
Our series revealed t(14;18) (q32;q21) in 6/43 cases
(14,3%). t(1;14) (p22;q32), never described in ocular
adnexa MALT lymphomas, was observed in 3/31
(9,7%), two of which exhibited the gain of 3’ upstream
BCL10 gene signal (4%), whereas no case showed
t(11;18) (q21;q21). Moreover, BCL10 expression was
observed in 18/45 cases. In particular its nuclear
expression was revealed in 12/45 cases, cytoplasmic
expression in 5/45 and both cytoplasmic and nuclear
expression in 1/45. Statistical analysis demonstrated that
while BCL10 cytoplasmic expression is significantly
related to the presence of the investigated chromosomal
aberrations, in particular with t(14;18) (q32;q21),
BCL10 nuclear shuttling does not show any correlation
with these translocations. Our data support that BCL10
nuclear distribution is neither related to BCL10
rearrangement nor to other known translocations.
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Citation
Histology and Histopathology, vol. 29, nº 1, (2014)
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