Publication: p53 in breast cancer. Its relation to histological grade, lymph-node status, hormone receptors, cell-proliferation fraction (ki-67) and c-erbB-2. Immunohistochemical study of 153 cases
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Date
1995
Authors
Sirvent, J.J. ; Salvadó, M.T. ; Santafe, M. ; Martínez, S. ; Brunet, J. ; Alvaro, T. ; Palacios, J.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The mutation of the p53 gene is a common
phenomenon in numerous human tumors, leading to the
accumulation of nonfunctioning p53 protein in the cell
nucleus, which can be detected by immunohistochemistry.
In breast cancer, it has been suggested that the
overexpression of p53 protein in the nucleus is an
indicator of poor prognosis, which must be borne in
mind in selecting coadjuvant treatment for each patient.
This study is an immunohistochemical analysis of
p53 expression in 153 cases of mammary carcinoma,
correlating it with histological grade, axillary node
status, hormone receptors, cell-proliferation fraction and
expression of the c-erbB-2 oncoprotein.
Of al1 the breast-cancer tissue analyzed, 43.79% was
positive for p53. The overexpression of this protein
bears a direct statistically significant relationship to
histological grade, cell-proliferation fraction and c-erbB-
2, and an inverse relationship to estrogen and
progesterone receptors. No statistically significant
relationship was found with axillary node status.
The expression of p53 in poorly differentiated
tumors-commonly receptor negative and with a high
proliferation fraction-may indicate greater tumor
agressiveness and a high risk of relapse.
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