Publication: Identification of Benzodiazepine Use Based on Dried Blood Stains Analysis
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Date
2024-06-17
Authors
Fernández López, Lucía ; Rodríguez, Sandra ; Cánovas Cabanes, Alberto ; Teruel Fernández, Francisco Javier ; Almela Rojo, Pilar ; Hernández del Rincón, Juan Pedro ; Navarro Zaragoza, Javier ; Falcón Romero, María
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Publisher
MDPI
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DOI
https://doi.org/ 10.3390/ph17060799
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info:eu-repo/semantics/article
Description
Abstract
Biological matrices are typically used in forensic toxicological or pharmacological analysis:
mainly blood, vitreous humor or urine. However, there are many cases in which crimes are a
consequence of drug intoxication or drug abuse and they are not closed because over the months or
years the samples become altered or decomposed. A dried blood stains test (DBS-MS) has recently
been proposed to be used in drug toxicology when blood is found at a crime scene. This test could
help an investigator to reveal what a person had consumed before the perpetration of the crime.
In order to check the possibilities of this test, we analyzed several dried blood stains located on a
cotton fabric. Therefore, the aim of this study was to determine if the analysis of a dried blood spot
located on a cotton fabric could be an alternate source of obtaining toxicological results, particularly
regarding benzodiazepines. We splashed blood stains on cotton fabric with different concentrations
of the following benzodiazepines: alprazolam, bromazepam, clonazepam, diazepam and lorazepam,
which were dried for 96 h and subsequently quantified by high-performance liquid chromatography
coupled mass spectrometry (HPLC-MS). Our results show that it is possible to identify several
benzodiazepines contained in a cotton fabric blood stain; consequently, this method may add
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Citation
Fernández-López, L.;
Rodríguez, S.; Cánovas-Cabanes, A.;
Teruel-Fernández, F.-J.; Almela, P.; del
Rincón, J.-P.H.; Navarro-Zaragoza, J.;
Falcón, M. Identification of
Benzodiazepine Use Based on Dried
Blood Stains Analysis. Pharmaceuticals
2024, 17, 799. https://doi.org/
10.3390/ph17060799
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