Publication:
Molecular pathology of adenoid cystic carcinoma

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Wei-40-1519-1528-2025 (1).pdf(6.78 MB)
Date
2025
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Authors
Wei Shuanzeng ; Pei Jianming ; Zhang Paul J.L.
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Publisher
Universidad de Murcia, Departamento de Histología e Histopatología
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Biología Celular e Histología
DOI
https://doi.org/10.14670/HH-18-915
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info:eu-repo/semantics/article
Description
Abstract
Adenoid cystic carcinoma (ACC) is a slow-growing but locally aggressive salivary gland tumor. ACC is composed of ductal/tubular epithelial cells and basal/myoepithelial cells, which form cribriform, tubular, and solid growth patterns in variable combinations and dominance. ACC from different anatomic sites have similar morphological, molecular, and genetic changes. The key molecular alteration in ACC is chromosomal fusion/rearrangement/trans-location involving MYB or MYBL1, usually with NFIB as a fusion partner. In this review, we summarize the pathology and molecular alterations in ACC and their clinical significance
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Adenoid cystic carcinoma , Pathology , Pathogenesis , Molecular , Genetic
Citation
Histology and Histopathology, volúmen 40, nº 10 (2025)
URI
http://hdl.handle.net/10201/167609
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Histology and histopathology Vol.40,nº10 (2025)
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