Publication: Tumor cell "dead or alive": Caspase and survivin regulate cell death, cell cycle and cell survival
Authors
Suzuki, A. ; Shiraki, K.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Cell death and cell cycle progression are two
sides of the same coin, and these two different
phenomenons are regulated moderately to maintain the
cellular homeostasis. Tumor is one of the disease states
produced as a result of the disintegrated regulation and is
characterized as cells showing an irreversible
progression of cell cycle and a resistance to cell death
signaling. Severa1 investigations have been performed
for the understanding of cell death or cell cycle, and cell
death research has remarkably progressed in these 10
years. Caspase is a nomenclature referring to ICEICED-
3 cysteine proteinase family and plays a central role
during cell death. Recently, severa1 investigations raised
some possible hypotheses that caspase is also involved
in cell cycle regulation. In this issue, therefore, we
review the molecular basis of cell death and cell cycle
regulated by caspase in tumor, especially hepatocellular
carcinoma cells.
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