Person:
Blanco Carnero, José Eliseo

Profile Picture
Name
Blanco Carnero, José Eliseo
publication.page.department
Universidad de Murcia. Departamento de Cirugía, Pediatría, Obstetriciay Ginecología
Repository logoRepository logoRepository logoRepository logo

Filters

111
2013 - 20192
2
2
Reset filters

Settings

Start date: 2013 × End date: 2019 ×

Search Results

Now showing 1 - 2 of 2
  • Thumbnail Image
    Publication
    Restricted
    In vivo kinetic study of materno-fetal fatty acid transfer in obese and normal weight pregnant women
    (2019-10) Gázquez, Antonio; Van Harskamp, Dewin; Perazzolo, Simone; Oosterink, J. Efraim; Demmelmair, Hans; Schierbeek, Henk; Sengers, Bram G.; Lewis, Rohan M.; Van Goudoever, Johannes B.; Koletzko, Berthold; Larqué, Elvira; Blanco Carnero, José Eliseo; Prieto Sánchez, María Teresa; Cirugía, Pediatría y Obstetricia y Ginecología; Fisiología
    Placental structure and function can be modified as a result of maternal obesity affecting materno-fetal fatty acids (FA) transport. We report for the first time, in humans and in vivo, the kinetics of placental FA transfer in normo-weight and in normolipemic obese pregnant women using stable isotopes. The administration of different tracer FA with similar behaviour to the mother at different time points allows the collection of kinetic information on materno-fetal transfer of FA despite only one sample of placenta and cord can be collected per subject. Computational modelling showed a good fit to the data when considering all maternal plasma lipid classes but not when based only on non-esterified FA. The novel approach using multiple tracer FA administration combined with computational modelling shows a consistent time course of placental tracer FA and predicted total FA accumulation.
  • Thumbnail Image
    Publication
    Open Access
    Influencia del sobrepeso y la obesidad en la transferencia placentaria de ácidos grasos en gestantes con diabetes gestacional.
    (2013-07-01) Blanco Carnero, José Eliseo; Larqué Daza, Elvira; Parrilla Paricio, Juan José; Departamento de Fisiología
    PALABRAS CLAVE: Diabetes gestacional, ácidos grasos poliinsaturados, transferencia placentaria, obesidad. El objetivo del estudio fue evaluar la influencia del sobrepeso y obesidad en las gestantes con diabetes gestacional, en su perfil de ácidos grasos en suero materno y en el aporte transplacentario al feto, comparándolo con gestantes normopeso con y sin diabetes gestacional. El sobrepeso y la obesidad en gestantes con DMG no modificó la concentración total de ácidos grasos o sus porcentajes, en suero materno ni en el tejido placentario. Sin embargo, en suero de vena umbilical la DMG con o sin obesidad disminuyó la concentración total de ácidos grasos fetales y los porcentajes de los ácidos grasos esenciales y condicionalmente esenciales. Como conclusión podemos afirmar que la diabetes gestacional con o sin obesidad disminuye los niveles de ácidos grasos poliinsaturados en sangre de cordón, lo cual puede ser debido a una alteración en el transporte placentario de estos nutrientes. KEY WORDS: Gestational diabetes mellitus, long-chain polyunsaturated fatty acids, placental transfer, obesity. The aim of the study was to evaluate the influence of overweight and obesity in pregnant women with gestational diabetes in their fatty acid profile in maternal serum and fetal transplacental intake, compared with normal weight pregnant women with and without gestational diabetes Overweight and obesity in pregnant women with gestational diabetes mellitus did not alter the total concentration of fatty acids or their percentage in maternal serum or placental tissue. However, in the umbilical vein serum with or without obesity gestational diabetes mellitus decreased total fatty acid concentration and the percentage of fetal essential fatty acids and conditionally essential. We can affirm that gestational diabetes mellitus, with or without overweight or obesity, reduces polyunsaturated fatty acids levels in cord blood, which might be due to impaired placental transport of these nutrients.
Ir a Estadísticas