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García-Estañ López, Joaquín

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García-Estañ López, Joaquín
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Universidad de Murcia. Departamento de Fisiología
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Subject: Hipertensión arterial ×

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    Evaluation of the effects of mulberry leaf extracts Morus alba L. on cardiovascular, renal, and platelet function in experimental arterial hypertension
    (MDPI, 2024-12-27) Aghdam, Masoud Akbari; Pagán, Ana; García-Estañ López, Joaquín; Marín Atucha, Noemí; Fisiología; Facultades de la UMU::Facultad de Medicina
    Introduction: Numerous epidemiological studies have demonstrated that consuming foods rich in polyphenols and flavonoids can have beneficial effects on various diseases, including arterial hypertension (HTN). Recent research from our laboratory has shown that certain flavonoids exhibit antihypertensive properties in several animal models of HTN. Our objective was to evaluate the effect of Morus alba L. (white mulberry) extracts in an experimental HTN model characterized by nitric oxide (NO) deficiency. Methods: Male Sprague-Dawley rats were divided into four groups: a control group, hypertensive rats treated with an NO synthesis inhibitor (L-NAME) in drinking water for six weeks, L-NAME rats treated with Morus alba L. extract, and L-NAME rats treated simultaneously with captopril. After six weeks of treatment, we measured blood pressure, endothelial vascular function in the aorta, and platelet aggregation function. Results: Morus alba L. extract partially prevented the development of arterial hypertension due to NO deficiency, although it did not completely normalize blood pressure as captopril did. The extract reduced the excessive vasoconstrictor response to phenylephrine in aortic rings and improved vasodilation in response to acetylcholine, with both effects dependent on increased NO production. Morus alba L. extract also reduced the increased platelet aggregation in response to ADP and collagen in hypertensive animals, although it did not fully normalize this function. Conclusions: Morus alba L. extract demonstrates antihypertensive effects, improves vascular reactivity, and reduces platelet aggregation in a model of arterial hypertension. These effects are primarily related to an increase in nitric oxide activity.
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    Effects of flavonoids in experimental models of arterial hypertension
    (Bentham Science Publishers, 2021-08-12) Marín Atucha, Noemí; Romecín, Paola; Vargas, Félix; García-Estañ López, Joaquín; Fisiología; Facultades de la UMU::Facultad de Medicina
    Flavonoids are a class of substances of a vegetal origin with many interesting actions from the point of view of human disease. Interest in flavonoids in the diet has increased in recent years due to the publication of basic, clinical and epidemiological studies that have shown a whole array of salutary effects related to intake of flavonols and flavones as well as a lower morbility and mortality of cardiovascular diseases. Since arterial hypertension is the most common modifiable risk factor for cardiovascular diseases, this review will focus mainly on the effects of flavonoids on the cardiovascular system with relation to the elevation of blood pressure. Its antihypertensive effects as well as the many investigations performed in experimental models of arterial hypertension, are reviewed in this mini-review.
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