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López Nicolás, Rubén

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López Nicolás, Rubén
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Universidad de Murcia. Departamento de Tecnología de los Alimentos,Nutrición y Bromatología
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    Folate fortification of white and whole-grain bread by adding Swiss chard and spinach. Acceptability by consumers
    (Elsevier, 0016-05-14) López Nicolás, Rubén; Frontela Saseta, María del Carmen; González-Abellán, Raquel; Barado-Piqueras, Ana; Perez-Conesa, Darío; Ros Berruezo, Gaspar; Tecnología de Alimentos, Nutrición y Bromatología
    The aim of this work was to study the effect of bread-making on the content of endogenous folate of white and whole-grain bread fortified with either Swiss chard or spinach at 20 g/100 g and 40 g/100 g measured by HPLC (H4-folate and 5-CH3-H4-folate); and to assess the sensory acceptability of folatefortified breads compared to non-fortified breads. The fortification of breads with 20 g/100 g and 40 g/100 g vegetables significantly (p < 0.001) increased the total folate content (from 19.9 to 57.9 mg/ 100 g in white bread and from 37.4 to 75.5 mg/100 g in whole-grain bread). Moreover, 40 g/100 g Swiss chard- and spinach-fortified breads obtained higher scores in overall acceptability than 20 g/100 g fortified or control bread for both white and whole-grain breads. The consumption of two servings (56 g each) per day of 40 g/100 g fortified bread would meet the daily folate requirements by 14.3e21.8% in adults and 9.6e14.5% in some special states like women of child-bearing age.
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    Satiety hormone secretion induced by a carob-based formulation (Csat®) after simulated gastrointestinal digestion and colonic fermentation in STC-1 cells
    (Elsevier, 0001-07-26) Benito-Vázquez, Iván; Rosell, María de los Ángeles; Lates-Profir, Natalia; Díez Municio, Marina; Moreno, Francisco Javier; Frontela Saseta, María del Carmen; López Nicolás, Rubén; Tecnología de Alimentos, Nutrición y Bromatología
    Csat® is a carob-derived based product standardized in galactomannans, inositols, and gallic acid, with potential applications in weight management and metabolic health. This study evaluated the effects of Csat® on satietyrelated enteroendocrine signalling after simulated gastrointestinal digestion and colonic fermentation. A standardized INFOGEST in vitro digestion model was combined with batch colonic fermentation using human faecal inoculum, and the resulting fractions were tested in STC-1 cells to quantify glucagon-like peptide-1 (GLP-1) and cholecystokinin (CCK) secretion. Digestive stability of key bioactive compounds was assessed by HPLC-MS. Undigested Csat® did not stimulate hormone secretion, whereas gastric digestion induced the strongest enteroendocrine response, significantly increasing both GLP-1 and CCK release. The intestinal soluble phase maintained a moderate stimulatory effect. During colonic fermentation, galactomannans were extensively degraded, while pinitol remained stable and gallic acid showed variable recovery. Fermentation kinetics revealed active microbial metabolism, with early fermentation associated with the highest endocrine response. GLP-1 and CCK secretion peaked at 4 h fermentation and progressively declined at later stages. Overall, Csat® showed a marked phase-dependent endocrine activity, with gastrointestinal processing and early microbial fermentation generating the most bioactive fractions. These findings support the potential of Csat® to modulate satiety-related pathways through coordinated digestion- and microbiota-derived mechanisms.
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