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Víllora Cano, Gloria

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Víllora Cano, Gloria
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Universidad de Murcia. Departamento de Ingeniería Química
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    Complex polysaccharide-based nanocomposites for 2 oral insulin delivery
    (MDPI (Basel, Switzerland), 2020-01-15) Collado-González, Mar; Freitas, Alessandra R.; Santos, Ana Claudia; Ferreira, Nuno F.; Ferreri, Maria Cristina; Sequeira, Joana A.D.; Díaz Baños, F. Guillermo; Víllora Cano, Gloria; Veiga, Francisco; Ribeiro, Antonio; Carissimi, Guzmán; Química Física
    Polyelectrolyte nanocomposites rarely reach a stable state and aggregation often occurs. Here, we report the synthesis of nanocomposites for the oral delivery of insulin composed of alginate, dextran sulfate, poly-(ethyleneglycol) 4000, Poloxamer 188®, chitosan, and BSA. Chitosan seems to be essential for the final size of the nanocomposites. When the chitosan concentration used in the synthesis is 10-4 gcm-3, nanocomposites, microcomposites and milimetric composites are obtained. Reducing the chitosan concentration to 10-5 or 10-7 gcm-3 yields nanocomposites of 400-600 nm or 800-900 nm hydrodynamic diameter, respectively, measured by DLS. According to our results, the molecular weight of chitosan has little influence on the size of the composites. The enhanced stability of the newest nanocomposites synthesized was assessed with LUMiSizer®. The rounded shapes of the nanocomposites were confirmed by scanning electron microscopy. Analysis by HPLC revealed that, after loaded with insulin, about 80% of the drug was released from our nanocomposites.
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    Open Access
    Assessing chemical toxicity of ionic liquids on Vibrio fischeri: Correlation with structure and composition
    (Pergamon – Elsevier Science Ltd, 2016-04-11) Hidalgo, Juana M; García Montalbán, Mercedes; Salinas Hidalgo, María Dolores; Collado-González, Mar; Díaz Baños, F. Guillermo; Víllora Cano, Gloria; Biología Celular e Histología
    One of the most important properties of the ionic liquids (ILs) is their non-volatility. However, they are wide soluble in water. For this reason, they can be released to aquatic ecosystems and to contribute to water pollution. Nevertheless, toxicological data related to ionic liquids is scarce in literature because of the great number of possible ionic liquids synthesized. The present work reports the toxicity of twenty-nine imidazolium-, pyridinium- and ammonium-based ionic liquids towards the luminescent bacteria Vibrio fischeri. Some of the effects analyzed on the toxicity have been the type of anion, the length of the alkyl chain of the cation, the cation core and the presence of a functionalized side chain in the cation. These results have showed that the main influence on the toxicity of the ILs is the alkyl chain length. A Quantitative Structure-Activity Relationships (QSAR) method has been used to validate our results obtaining a very good agreement.
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