López González, Laura

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López González, Laura

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Anatomía Humana y Psicobiología

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Open Access
Elevated tissue expression of RANKL and RANK is associated with poorer survival rates in pancreatic cancer patients
(Universidad de Murcia, Departamento de Biologia Celular e Histiologia, 2024) Ortega, Miguel A; Jiménez Álvarez, Laura; Fraile Martinez, Oscar; Garcia Montero, Cielo; Leon Oliva, Diego De; Toledo Lobo, M. Val; Palacios, Esther; Granado, Paula; Esteban, Alfonso; Guijarro, Luis G.; Pekarek, Leonel; Asúnsolo, Ángel; Buján, Julia; García Honduvilla, Natalio; Álvarez Mon, Melchor; Saez, Miguel A; Díaz Pedrero, Raúl; López González, Laura
Pancreatic cancer is a highly lethal malignancy with a growing incidence reported worldwide. Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer, which is often diagnosed at advanced stages, making its prognosis and medical management difficult. The identification of histopathological biomarkers has allowed a more precise stratification of pancreatic cancer patients, providing additional information about their prognosis and offering possible therapeutic targets to be explored. The prognostic value of the receptor activator of nuclear factor-kappa B (RANK) and its ligand (RANKL) has been evaluated in breast and prostate tumors, however, their usefulness has not been assessed in pancreatic cancer. In the present work, we analyzed the relationship between the protein expression of RANK and RANKL with the survival of 41 patients with pancreatic cancer followed for 60 months, by performing immunohisto-chemistry and Kaplan-Meier curves. Our results demonstrate a direct association of high expression levels of RANK and RANKL with poorer survival of pancreatic cancer patients in comparison to those with low/medium and null expression levels of both markers. Further studies should be conducted to explore the carcinogenic role of both components in this type of tumor, as well as additional promising translational uses.
Open Access
Data base: Estudio satisfacción. Uso de gamificación en docencia de Anatomía humana (encuestas)
López González, Laura; Anatomía Humana y Psicobiología; Facultad de Medicina
Open Access
Memoria Proyecto: uso de un sistema inteligente autónomo Para el aprendizaje de Anatomía Humana
González Sequeros Ofelia; Fernández Alemán, José Luis; López González, Laura; Anatomía Humana y Psicobiología; Facultad de Medicina
Open Access
Anatomía clínica: Implantes cigomáticos
López González, Laura; Anatomía Humana y Psicobiología; Facultad de Medicina
Open Access
Atlas de disección: guía de estudio Neuroanatomía II
López González, Laura; Anatomía Humana y Psicobiología; Facultad de Medicina
Open Access
Tema 6. Estudio topográfico e importancia clínica del espacio máxilofaringeo
López González, Laura; Anatomía Humana y Psicobiología; Facultad de Medicina
Open Access
tema 1: Constitución anatómica de las diferentes regiones de la cavidad bucal: región geniana, labios, lengua, paladar
López González, Laura; Anatomía Humana y Psicobiología; Facultad de Medicina
Open Access
Taking the pulse of a classroom with a gamified audience response system
(Elsevier, 2021-10-13) López-Jiménez, Juan José; Fernández Alemán, José Luis; González Sequeros, Ofelia; Moros Valle, Begoña; García-Berná, José Alberto; Idri, Ali; Toval, Ambrosio; López González, Laura; Informática y Sistemas
Background and objective: This paper presents an empirical study of a gamified mobile-based assessment approach that can be used to engage students and improve their educational performance. Method: A gamified audience response system called G-SIDRA was employed. Three gamification elements were used to motivate students in classroom activities: badges for achievements to increase engagement, points to indicate progression and performance in the subject and ranking for promoting competitiveness. A total of 90 medical students in a General and Descriptive Anatomy of the Locomotor System course were taught using G-SIDRA in the academic year 2019/2020. Smart bracelets were configured to collect heart rate measurements from 30 students with the aim of evaluating the impact of the gamification elements. The control group consisted of a sample of 110 students enrolled on the same course in the academic year 2016/2017 using non-gamified SIDRA. Results: Statistically significant differences were found between multiple choice questions (MCQ) scores obtained by using SIDRA and G-SIDRA in the four experiments (U = 1.621,50, p < 0,01 for Exp1; U = 1.950,00, p < 0,01 for Exp2; U = 955,00, p < 0,01 for Exp3; U = 2.335,00, p < 0,01 for Exp4). In the students’ final exam grades, statistically significant differences between students that used G-SIDRA as opposed to SIDRA (T(157) = 3.992; p = 0.044) were obtained. Concerning gamification elements, statistically significantly differences were found in comparing the pulse increases after and before the badge event in the four experiments (U = 2.484,00, p = 0,038 for Exp1; U = 2.109,50, p = 0,046 for Exp2; U = 1.790,50, p = 0,025 for Exp3; U = 1.557,0, p = 0,048 for Exp4). However, there are not statistically significant differences between the pulse increases after and before the ranking event in the four experiments. In a 5-point Likert-type scale, the students expressed satisfaction with G-SIDRA (M = 4.552) and thought the system helped to better understand both theoretical and practical concepts ( M = 4.092). Their global assessment of the G-SIDRA platform was 4.471. Conclusions: Of the three gamification elements used in the study, only badge has an effect on heart rate. Better student responses and academic performance were achieved when using G-SIDRA. Nevertheless, more research is required to evaluate the impact of the gamification elements on the motivation, engagement and performance of students. Physiological measures are promising approaches for gamification elements evaluation.
Open Access
Advances in 3D bioprinting to enhance translational applications in bone tissue engineering and regenerative medicin
(Universidad de Murcia, Departamento de Biologia Celular e Histiologia, 2025) Ortega, Miguel A; Leon Oliva, Diego De; Liviu Boaru, Diego; Fraile-Martínez, Oscar; Garcia Montero, Cielo; Casanova, Carlos; García Honduvilla, Natalio; Buján, Julia; Saez, Miguel A; Álvarez Mon, Melchor; Velazquez De Castro, Amador; Acero, Julio; Barrena Blázquez, Silvestra; Diaz, Raul; López González, Laura
Bone defects are due to trauma, infections, tumors, or aging, including bone fractures, bone metastases, osteoporosis, or osteoarthritis. The global burden of these demands research into innovative strategies that overcome the limitations of conventional autografts. In this sense, the development of three-dimensional (3D) bioprinting has emerged as a promising approach in the field of tissue engineering and regenerative medicine (TERM) for the on-demand generation and transplantation of tissues and organs, including bone. It combines biological materials and living cells, which are precisely positioned layer by layer. Despite obtaining some promising results, 3D bioprinting of bone tissue still faces several challenges, such as generating an effective vascular network to increase tissue viability. In this review, we aim to collect the main knowledge on methods and techniques of 3D bioprinting. Then, we will review the main biomaterials, their composition, and the rationale for their application in 3D bioprinting for the TERM of bone.
Open Access
Tema 5. Inervación de la región orofacial y del aparato estomatognático
López González, Laura; Anatomía Humana y Psicobiología; Facultad de Medicina