Motas Guzmán, Miguel

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Motas Guzmán, Miguel

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Motas Guzmán, Miguel

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Universidad de Murcia. Departamento de Ciencias Sociosanitarias

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Effects of chlorpyrifos on cell death and cellular phenotypic specification of human neural stem cells
(2019-05-18) Sandoval, L; Rosca, A; Oniga, A; Zambrano, A; Ramos, JJ; González, MC; Liste, I; Motas Guzmán, Miguel; Ciencias Sociosanitarias
Chlorpyrifos (CPF) is an organophosphate pesticide widely used in agriculture, whose traditional and wellknown mechanism of action is the inhibition of the enzyme Acetylcholinesterase (AChE). Subacute exposures to CPF have been associated with alterations different from the inhibition of AChE. Because of the vulnerability of the developing nervous system, prenatal and early postnatal exposures are of special concern. Human neural stem cells (hNSC) provide the opportunity to study early stages of neural development and may be a valuable tool for developmental neurotoxicology (DNT). In the current work, the cell line hNS1 was used as a model system with the aim of validating this cell line as a reliable testing method. To evaluate the effects of CPF on early developmental stages, hNS1 cells were exposed to different concentrations of the pesticide and cell death, proliferation and cell fate specification were analyzed under differentiation conditions. Since hNS1 cells responded to CPF in a similar way to other human cell lines, we consider it may be a valid model for DNT chemical assessment. CPF induced apoptotic cell death only at the highest doses tested, suggesting that it is not toxic for the specific developmental stage here addressed under short term exposure. In addition, the higher doses of CPF promoted the generation of astroglial cells, without affecting neurogenesis.
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Gastrointestinal parasites in Chinstrap Penguins from Deception Island, South Shetlands, Antarctica
(Springer, 2012-03-28) Vidal, Virginia; Ortiz, Juana; Díaz, J. I.; Ruiz de Ybáñez Carnero, María del Rocío; Amat, M.T.; Palacios, M. J.; Benzal, Jesús; Valera, Francisco; de la Cruz, C.; Barbosa, Andrés; Motas Guzmán, Miguel; Sanidad Animal
Knowledge about parasites of Antarctic birds is fragmented and scarce. The aim of this work is to contribute to the knowledge of gastrointestinal parasites of the Chinstrap Penguin (Pygoscelis antarctica) from Deception Island (South Shetlands, Antarctica). Gastrointestinal tracts of 64 fresh dead individuals (61 chicks and three adults) were collected from December 2006 to February 2009 and examined for macroparasites. Three adult parasite species were found: two Cestoda species (Parorchites zederi and Tetrabothrius pauliani) and one Nematoda species (Stegophorus macronectes). Also, immature acanthocephalans (Corynosoma sp.) were found in one penguin. The low parasite richness observed could be related to the stenophagic and pelagic diet of the host species. False negatives were found in coprological studies.
Open Access
Uncertainty and associated risks in the analysis of pesticides in homogeneous paprika samples
(Elsevier, 2023-12-15) Veiga-del-Baño, José Manuel; Cuenca-Martínez, Juan José; Andreo-Martínez, Pedro; Cámara, Miguel Angel; Oliva, José; Motas Guzmán, Miguel; Química Agrícola, Geología y Edafología
In this study, risk estimation based on sampling and subsampling uncertainty was performed for pesticide analysis in homogeneous spice products such as paprika. The results of the subsampling were also used to estimate the minimum weight necessary in subsampling to minimize overall uncertainty. The results show that subsampling has more uncertainty than sampling in the product due to high homogeneity in the manufacturer’s batch. On the other hand, results using the Monte Carlo (MC) simulation on the size of the subsample indicate that uncertainty is lower for weights between 20 and 30 g and increases for sample sizes of 100 g. A sample size of 30 g was used for saffron, and the values simulated with the MC method were confirmed.
Open Access
Science production of pesticide residues in honey research: A descriptive bibliometric study
(Elsevier, 2020-10) Andreo-Martínez, Pedro; Oliva, José; Giménez-Castillo, Juan José; Quesada-Medina, Joaquín; Cámara, Miguel Ángel; Motas Guzmán, Miguel; Química Agrícola, Geología y Edafología
This work aims to provide a comprehensive study of the available research information on pesticide residues in honey through literature analysis. The research advancements within this research field from 1948 to 2019 are addressed using the Web of Science database. The results from the 685 articles analyzed indicate that this research field is in the focus of interest nowadays (Price index: 47.5 %). The yearly production increased steadily from 2001 on, and authors, journals, and institutions followed Lotka's law. On the other hand, Pico, Y (Spain) (2.5 %), Journal of Chromatography A (5.8 %), the USA (15.0 %) and Agricultural Research Service (USA) (4.0 %) were the most productive author, journal, country and institution, respectively. The research hotspots of this field, according to keyword analysis, are related to the chromatographic techniques for the determination of pesticides such as imidacloprid, neonicotinoids, or coumaphos in honey and derivate products such as propolis and wax.
Open Access
Animales envenenados: la experiencia de diez años del servicio de toxicología de la universidad de murcia
(Murcia: Universidad de Murcia, Servicio de Publicaciones, 2002) Romero Gombau, Alberto Damian; García Fernández, Antonio Juan; María Mójica, Pedro; Martínez López, Emma; Motas Guzmán, Miguel; Navas Ruiz, Isabel Maria; Facultad de Veterinaria
Open Access
Envenenamiento e intoxicaciones de fauna silvetre y dómestica en la región de Murcia durante el bienio 2005-2006
(Murcia, Universidad de Murcia, Servicio de Publicaciones, 2007) Jerez Darias, Luis Manuel; Almela Pérez, Ramón; Clavel, C.; Bayón del Río, Alejandro Ángel; Motas Guzmán, Miguel; Facultad de Veterinaria
envenenamiento o intoxicación en animales silvestres (y domésticos en menor medida), recibidos durante el bienio 2005-2006 en el Servicio de Toxicología del Centro de Recuperación de Fauna Silvestre “El Valle” (Murcia). Dicha revisión permite ofrecer información epidemiológica acerca de los principales agentes tóxicos relacionados con envenenamientos de animales de vida silvestre en el Sureste de España, así como de las causas que conducen a provocarlos. De los 94 casos recibidos y analizados, 41 fueron positivos, con un balance total de 122 cadáveres. Plaguicidas, sobre todo insecticidas y rodenticidas, fueron las sustancias más frecuentemente involucradas. En concreto, aldicarb (29,54%), fentión (25,00%), carbofurano (15,90%) y monocrotofos (9,09%) son los compuestos más utilizados en la preparación de cebos para envenenamientos. La primavera y el invierno son las épocas del año en las que los envenenamientos son más numerosos, y mayoritariamente se producen en zonas rurales y de tradición cinegética.
Open Access
Mapping of emerging contaminants in coastal waters research: a bibliometric analysis of research output during 1986–2022
(Elsevier, 2023-08-04) Veiga del Baño, José Manuel; Cámara, Miguel Ángel; Oliva, José; Hernández Cegarra, Antonio Tomás; Andreo Martíneza, Pedro; Motas Guzmán, Miguel; Química Agrícola, Geología y Edafología
This bibliometric analysis provides the first overview of the literature on emerging contaminants in coastal waters. Bibexcel, Microsoft Excel, VOSviewer and the bibliometix R package software were used for bibliometric analysis and science mapping. 556 publications, published between 1986 and 2022, were retrieved from the Web of Science (WoS) database. The results showed that this field of research follows Price's law of exponential growth and has exploded since 2001. Authors, journals and institutions followed Lotka's law, and Price's index (43.4 %) showed that the field is far from being obsolete. The most influential institution is the Chinese Academy of Sciences, while authors from China, USA, Japan and Singapore have the most publications and international co-authorships. The leading journal is Marine Pollution Bulletin, with a focus on Environmental Science WoS category. Hot research areas focus on risk assessment of PCBs, organochlorine compounds and personal care products in surface water and wastewater.
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Estudio experimental, cinético, metabólico y morfológico en la exposición subcrónica a cadmio y plomo / Miguel Motas Guzmán ; directores Antonio Juan García Fernández, Maximiliano Gómez Zapata.
(Murcia : Universidad de Murcia, Facultad de Veterinaria, Departamento de Ciencias Sociosanitarias, Unidad Docente de Toxicología,, 1999) Gómez Zapata, Maximiliano; Motas Guzmán, Miguel; García Fernández, Antonio Juan
Open Access
Sunflower meal as cause of chronic copper poisoning in lambs in southeastern Spain
(Association Canadienne des médicins vétérinaries, 1999-11) García Fernández, Antonio Juan; María Mójica, Pedro; Motas Guzmán, Miguel; Navas Ruiz, Isabel Maria; Romero García, Diego; Ciencias Sociosanitarias
Sunflower meal with a copper/molybdenum ratio of 10 caused copper toxicosis in lambs. Copper must be analyzed on a dry matter basis in liver and renal cortex. Oral administration of molybdenum and thiosulfate had a certain effectiveness in sick animals. Care must be taken with feedstuffs made from copper-dependent plants.
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Mode of attachment and pathology caused by Parorchites zederi in three species of pygoscelid pengüins: Pygoscelis papua, Pygoscelis adeliae and Pygoscelis Antarctica in Antarctica
(Wildlife Disease Association, 2016-07-01) Martín, María A.; Ortiz Sánchez, Juana; Vidal, Virginia; Valera, Francisco; Benzal, Jesús; Cuervo, José J.; Cruz, Carlos de la; Belliure, Josabel; Martínez, Ana M.; Díaz, Julia I.; D'Amico, Verónica L.; Barbosa, Andrés; Seva Alcaraz, Juan; Jerez Rodríguez, Silvia; Motas Guzmán, Miguel; Sanidad Animal
We identified and compared gross and microscopic lesions associated with the cestode, Parorchites zederi, in the digestive tracts of three species of penguins (Spheniscidae): the Chinstrap (Pygoscelis antarctica), Gentoo (Pygoscelis papua), and Ade´lie penguins (Pygoscelis adeliae). The gastrointestinal tracts of 79 recently dead individuals (71 chicks and eight adults) were collected in locations throughout the Antarctic Peninsula during summer field trips in 2006–09. Parorchites zederi was found in the small intestine of 37 animals (47%), and 23 (62%) of these had parasite-associated lesions. The cestodes were either free in the intestinal lumen, clustered within mucosal ulcers, or deeply embedded in the intestinal wall. Histopathologic changes were most severe in adult Gentoo Penguins and included transmural fibrogranulomatous enteritis, hemorrhage, and edema. This report of pathology associated with P. zederi in the digestive tracts of penguins can serve as reference to monitor health in Antarctic birds associated with environmental changes.