2024-03-28T20:12:46Zhttps://digitum.um.es/digitumoai/requestoai:digitum.um.es:10201/360822020-02-16T00:32:11Zcom_10201_17677com_10201_19459com_10201_3col_10201_35885
Digitum: Repositorio Institucional de la Universidad de Murcia
author
Matsakas, Antonios
author
Patel, Ketan
2013-09-25T08:06:59Z
2013-09-25T08:06:59Z
2009
0213-3911
http://hdl.handle.net/10201/36082
The focus of the present review is to
assimilate current knowledge concerning the differing
signalling transduction cascades that control muscle
mass development and affect skeletal muscle phenotype
following exercise or nutritional uptake. Effects of
mechanical loading on protein synthesis are discussed.
Muscle growth control is regulated by the interplay of
growth promoting and growth suppressing factors,
which act in concert. Much emphasis has been placed on
understanding how increases in the rate of protein
synthesis are induced in skeletal muscle during the
adaptive process. One key point to emerge is that protein
synthesis following resistance exercise or increased
nutrient availability is mediated through changes in
signal transduction involving the phosphorylation of
mTOR and sequential activation of downstream targets.
On the other hand, AMPK activation plays an important
role in the inhibition of protein synthesis by suppressing
the function of multiple translation regulators of the
mTOR signalling pathway in response to cellular energy
depletion and low metabolic conditions. The effects of
exercise and/or nutritional uptake on the activation of
signalling molecules that regulate protein synthesis are
highlighted, providing a better understanding of the
molecular changes in the cell.
info:eu-repo/semantics/openAccess
Exercise
Nutrition
Intracellular signalling pathways regulating the adaptation of skeletal muscle to exercise and nutritional changes
info:eu-repo/semantics/article
URL
https://digitum.um.es/digitum//bitstream/10201/36082/1/Intracellular%20signalling%20pathways%20regulating%20the%20adaptation.pdf
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Intracellular signalling pathways regulating the adaptation.pdf
URL
https://digitum.um.es/digitum//bitstream/10201/36082/2/Intracellular%20signalling%20pathways%20regulating%20the%20adaptation.pdf.txt
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Intracellular signalling pathways regulating the adaptation.pdf.txt