2024-03-28T18:57:37Zhttps://digitum.um.es/digitumoai/requestoai:digitum.um.es:10201/226732020-02-12T00:32:35Zcom_10201_17677com_10201_19459com_10201_3col_10201_21278
Digitum: Repositorio Institucional de la Universidad de Murcia
author
Saba, S.R.
author
Vesely, D.L.
2011-06-30T12:03:04Z
2011-06-30T12:03:04Z
2006
0213-3911
http://hdl.handle.net/10201/22673
Four cardiac peptide hormones, i.e., vessel
dilator, long acting natriuretic peptide (LANP),
kaliuretic peptide, and atrial natriuretic peptide (ANP)
synthesized by the same gene decrease within 24 hours
up to 97% the number of human breast, colon,
pancreatic, and prostate adenocarcinoma cells as well as
human small-cell and squamous carcinomas of the lung
cells. These peptide hormones completely inhibit the
growth of human pancreatic adenocarcinomas growing
in athymic mice. Immunocytochemical investigations
have revealed that LANP, vessel dilator, kaliuretic
peptide and ANP localize to the nucleus and cytoplasm
of human pancreatic adenocarcinomas, which is
consistent with their ability to decrease DNA synthesis
in the nucleus of this cancer mediated by the
intracellular messenger cyclic GMP. These peptide
hormones also localize to the endothelium of capillaries
and fibroblasts within these cancers. These are the first
growth-inhibiting peptide hormones ever demonstrated
to localize to the nucleus. Their ability to decrease the
activation of growth promoting substances such as
Extracellular Receptor Kinase (ERK)-1/2 and Nuclear
Factor Kappa Beta (NFkB) suggests that in addition to
inhibiting DNA synthesis their ability to decrease the activation of growth promoting substances helps to
mediate their ability to inhibit the growth of human
cancers.
info:eu-repo/semantics/openAccess
Cancer
Nucleus
Cardiac natriuretic peptides: hormones with anticancer effects that localize to nucleus, cytoplasm,
endothelium, and fibroblasts of human cancers
info:eu-repo/semantics/article
URL
https://digitum.um.es/digitum//bitstream/10201/22673/1/Cardiac%20natriuretic%20peptides%20hormones%20with%20anticancer%20effects.pdf
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Cardiac natriuretic peptides hormones with anticancer effects.pdf
URL
https://digitum.um.es/digitum//bitstream/10201/22673/2/Cardiac%20natriuretic%20peptides%20hormones%20with%20anticancer%20effects.pdf.txt
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Cardiac natriuretic peptides hormones with anticancer effects.pdf.txt