Por favor, use este identificador para citar o enlazar este ítem:
http://hdl.handle.net/10201/47820
Twittear
Registro completo de metadatos
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Sundblad, Victoria | - |
dc.contributor.author | Croci, Diego O. | - |
dc.contributor.author | Rabinovich, Gabriel A. | - |
dc.date.accessioned | 2016-02-09T14:28:25Z | - |
dc.date.available | 2016-02-09T14:28:25Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1699-5848 | - |
dc.identifier.issn | 0213-3911 | - |
dc.identifier.uri | http://hdl.handle.net/10201/47820 | - |
dc.description.abstract | Galectin-3 belongs to a family of highly conserved animal lectins characterized by their ability to recognize multiple N-acetyllactosamine sequences, which can be displayed on both N- and O-glycans on cell surface glycoconjugates. Although first identified in macrophages, galectin-3 (also called ‘Mac-2, εBP, CBP35 or L-29’) has been found to be widely distributed in several tissues and developmental stages where, depending on its extracellular or intracellular localization, it can display a broad diversity of biological functions including immunomodulation, host-pathogen interactions, embryogenesis, angiogenesis, cell migration, wound healing and apoptosis. In spite of the existence of several reviews describing the multifunctional properties of galectin-3, an integrated view of the regulated expression of this glycan-binding protein in different normal tissues is lacking. Here we attempt to summarize and integrate available information on galectin-3 distribution in normal haematopoietic and non-haematopoietic tissues, mainly in adulthood, with only a brief reference to its expression during embryonic stages. In addition, given the multiplicity of biological roles attributed to this protein, a brief description of galectin-3 functions is also included. Understanding how galectin-3 is regulated in normal tissues will contribute to a rational design of approaches aimed at modulating galectin-3 expression and subcellular localization for experimental and therapeutic purposes. | es |
dc.format | application/pdf | es |
dc.format.extent | 19 | es |
dc.language | eng | es |
dc.publisher | Murcia: F. Hernández | es |
dc.relation.ispartof | Histology and histopathology, Vol. 26, nº 2 (2011) | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | Physiological expression | es |
dc.subject | Normal tissue | es |
dc.subject.other | 616 - Patología. Medicina clínica. Oncología | es |
dc.title | Regulated expression of galectin-3, a multifunctional glycan-binding protein, in haematopoietic and non-haematopoietic tissues | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol.26, nº2 (2011) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Sundblad-26-247-265-2011.pdf | 597,54 kB | Adobe PDF | Visualizar/Abrir |
Los ítems de Digitum están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.