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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Lu, Xinquan | es |
dc.contributor.author | Li, Huixiang | es |
dc.contributor.author | Xu, Kejia | - |
dc.contributor.author | Nesland, Jahn M. | - |
dc.contributor.author | Suo, Zhenhe | - |
dc.date.accessioned | 2014-01-09T10:37:31Z | - |
dc.date.available | 2014-01-09T10:37:31Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0213-3911 | es |
dc.identifier.uri | http://hdl.handle.net/10201/37545 | - |
dc.description.abstract | The existence of mammary epithelial stem/progenitor cells has been demonstrated in MUC-1-/ ESA+ subpopulations of breast epithelial cells. However, knowledge about the expression and localization in benign and malignant breast lesions is unknown. Using a double-staining immunohistochemistry method, we investigated MUC-1-/ESA+ cells in 10 normal breast tissues, 49 cases with fibrocystic disease, 40 fibroadenomas, 36 invasive ductal carcinomas and the breast cancer cell lines MCF-7 and MDA-MB-468. In normal breast tissues MUC-1-/ESA+ cells were mainly found in the suprabasal layer, but under the apical surface of the duct/alveolus. In the hyperplastic areas of fibrocystic disease, the number of this subpopulation of cells was higher than that in hypoplastic areas and in fibroadenomas. In invasive ductal carcinoma, the MMUC-1-/ESA+ cells were heterogeneously present in different carcinoma nests. In the MCF-7 cell line most cells were MUC-1-/ESA+, and in the MDA-MB-468 cell line MUC-1-/ESA+ cells and MUC-1-/ESA+ cells were almost equal. Our results show that the MUC-1-/ESA+ subpopulation increases in fibrocystic disease within the hyperplastic areas, and varies in benign and malignant breast tumours, indicating that breast carcinogenesis may develop from malignant changes of normal MUC-1-/ESA+ cells. | es |
dc.format | application/pdf | es |
dc.format.extent | 10 | es |
dc.language | eng | es |
dc.publisher | Murcia : F. Hernández | es |
dc.relation.ispartof | Histology and histopathology | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | Mammary gland | es |
dc.subject | Immunohistochemistry | es |
dc.subject.other | 616 - Patología. Medicina clínica. Oncología | es |
dc.title | MUC-1-ESA+ progenitor cells in normal benign and malignant human breast epithelial cells | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol.24,nº11 (2009) |
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MUC1ESA progenitor cells in normal benign and malignant human breast epithelial cells.pdf | 14,22 MB | Adobe PDF | Visualizar/Abrir |
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