Please use this identifier to cite or link to this item: http://hdl.handle.net/10201/37545

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dc.contributor.authorLu, Xinquanes
dc.contributor.authorLi, Huixianges
dc.contributor.authorXu, Kejia-
dc.contributor.authorNesland, Jahn M.-
dc.contributor.authorSuo, Zhenhe-
dc.date.accessioned2014-01-09T10:37:31Z-
dc.date.available2014-01-09T10:37:31Z-
dc.date.issued2009-
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/37545-
dc.description.abstractThe existence of mammary epithelial stem/progenitor cells has been demonstrated in MUC-1-/ ESA+ subpopulations of breast epithelial cells. However, knowledge about the expression and localization in benign and malignant breast lesions is unknown. Using a double-staining immunohistochemistry method, we investigated MUC-1-/ESA+ cells in 10 normal breast tissues, 49 cases with fibrocystic disease, 40 fibroadenomas, 36 invasive ductal carcinomas and the breast cancer cell lines MCF-7 and MDA-MB-468. In normal breast tissues MUC-1-/ESA+ cells were mainly found in the suprabasal layer, but under the apical surface of the duct/alveolus. In the hyperplastic areas of fibrocystic disease, the number of this subpopulation of cells was higher than that in hypoplastic areas and in fibroadenomas. In invasive ductal carcinoma, the MMUC-1-/ESA+ cells were heterogeneously present in different carcinoma nests. In the MCF-7 cell line most cells were MUC-1-/ESA+, and in the MDA-MB-468 cell line MUC-1-/ESA+ cells and MUC-1-/ESA+ cells were almost equal. Our results show that the MUC-1-/ESA+ subpopulation increases in fibrocystic disease within the hyperplastic areas, and varies in benign and malignant breast tumours, indicating that breast carcinogenesis may develop from malignant changes of normal MUC-1-/ESA+ cells.es
dc.formatapplication/pdfes
dc.format.extent10es
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectMammary glandes
dc.subjectImmunohistochemistryes
dc.subject.other616 - Patología. Medicina clínica. Oncologíaes
dc.titleMUC-1-ESA+ progenitor cells in normal benign and malignant human breast epithelial cellses
dc.typeinfo:eu-repo/semantics/articlees
Appears in Collections:Vol.24,nº11 (2009)

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