Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10201/21558

Registro completo de metadatos
Campo DCValorLengua/Idioma
dc.contributor.authorStröm, Å.es
dc.contributor.authorAhlqvist, E.es
dc.contributor.authorFranzé, Adela-
dc.contributor.authorHeinegård, D.-
dc.contributor.authorHultghrdh-Nilsson, A.-
dc.date.accessioned2011-06-08T09:08:20Z-
dc.date.available2011-06-08T09:08:20Z-
dc.date.issued2004-
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/21558-
dc.description.abstractDuring accelerated vascular remodeling such as in atherosclerosis, the composition of the extracellular matrix becomes altered. The matrix components of the diseased artery influence cellular processes such as adhesion, migration and proliferation. Furthermore, in atherosclerosis, the inability of the cells within the lesion to produce a mechanically stable matrix may lead to plaque rupture. In this immunohistochemical study of atherosclerotic mice aorta, we have reviewed the presence of ECM components with roles in maintaining tissue structure and function. These components include osteopontin and COMP as well as the leucine rich repeats proteins decorin, PRELP, and fibromodulin. Immunohistochemistry demonstrated presence of osteopontin, COMP, decorin, PRELP and fibromodulin in lesion areas of ApoE/LDLr deficient mice. Some advanced lesions exhibited areas of cartilage-like morphology and were shown to represent cartilage by their content of the cartilage specific proteins collagen II and aggrecan. The results suggest that cartilageassociated cell/collagen binding ECM proteins may be involved in the pathogenesis of atherosclerosis.es
dc.formatapplication/pdfes
dc.format.extent11es
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectAtherosclerosises
dc.subjectExtracellular matrixes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titleExtracellular matrix components in atherosclerotic arteries of Apo E/LDL receptor deficient mice: An immunohistochemical studyes
dc.typeinfo:eu-repo/semantics/articlees
Aparece en las colecciones:Vol.19, nº 2 (2004)

Ficheros en este ítem:
Fichero Descripción TamañoFormato 
Extracellular matrix components in.pdf23,97 MBAdobe PDFVista previa
Visualizar/Abrir


Los ítems de Digitum están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.