Digitum Colección:
http://hdl.handle.net/10201/123211
2024-03-28T15:28:49ZThe role of the non-ciliated bronchiolar cell in tolerance to inhaled vanadium of the bronchiolar epithelium
http://hdl.handle.net/10201/125793
Título: The role of the non-ciliated bronchiolar cell in tolerance to inhaled vanadium of the bronchiolar epithelium
Autor/es principal/es: López Valdez, Nelly; Guerrero Palomo, Gabriela; Rojas-Lemus, Marcela; Bizarro-Nevares, Patricia; González-Villalva, Adriana; Ustarroz-Cano, Martha; Rivera-Fernández, Norma
Resumen: The Non-Ciliated Bronchiolar Cell (NCBC)
is responsible for the defense and maintenance of the
bronchiolar epithelium. Several cellular defense
mechanisms have been associated with an increase in the
secretion of CC16 and changes in the phenotype of the
cell; these mechanisms could be linked to tolerance to
the damage due to exposure to inhaled Particulate Matter
(PM) of the epithelium. These defense mechanisms have
not been sufficiently explored. In this article, we studied
the response of the NCBC to inhaled vanadium, an
element which adheres to PM. This response was
measured by the changes in the phenotype of the NCBC
and the secretion of CC16 in a mouse model. Mice were
exposed in two phases to different vanadium
concentrations; 1.56 mg/m 3 in the first phase and 2.57
mg/m3 in the second phase. Mice were sacrificed on the
2nd, 4th, 5th, 6th and 8th weeks. In the second phase, we
observed the following: sloughing of the NCBC,
hyperplasia and small inflammatory foci remained
without changes and that the expression of CC16 was
higher in this phase than in phase I. We also observed a
change in the phenotype with a slow decrease in both
phases. The increase in the secretion of CC16 and the
phenotype reversion could be due to the anti-
inflammatory activity of CC16. The changes observed in
the second phase could be attributed to the tolerance to
inhaled vanadium.2020-01-01T00:00:00ZPTK7 expression is associated with lymph node metastasis, ALK and EGFR mutations in lung adenocarcinomas
http://hdl.handle.net/10201/125792
Título: PTK7 expression is associated with lymph node metastasis, ALK and EGFR mutations in lung adenocarcinomas
Autor/es principal/es: Jiang, Wei; He, Jing; Lv, Bihong; Xi, Xiaoxiang; He, Guangming; He, Jingkang
Resumen: Non-small cell lung cancer (NSCLC) is one
of the leading causes of cancer death worldwide. Lung
adenocarcinoma is the main tumor type of NSCLC.
Recent advances in the molecular characterization and
personalized therapies have improved NSCLC patient
prognosis. Previous studies showed that protein tyrosine
kinase 7 (PTK7) plays an important role in human
cancers. However, the role of PTK7 has not been
investigated. PTK7 expression was assessed by
immunohistochemistry in 95 patients with lung
adenocarcinoma. Correlations of PTK7 expression levels
with clinicopathological parameters, EGFR mutation and
EML4-ALK fusion were examined. Positive PTK7
expression was detected in 47.4% of lung adeno-
carcinoma. PTK7 expression was associated with gender
(P=0.024), lymph node metastasis (P<0.001), ALK
mutation (P=0.050), and EGFR mutations (P=0.014). No
significant association was found between PTK7
expression and age (P=0.831), differentiation (P=0.494),
adenocarcinoma subtype (P=0.098) and Ki67 (P=0.473).
Our data suggest that PTK7 plays an oncogenic role in
lung adenocarcinoma and may be a molecular marker for
lymph node metastasis.2020-01-01T00:00:00ZDiagnostic utility of CD205 in breast cancer: Simultaneous detection of myoepithelial cells and dendritic cells in breast tissue by CD205
http://hdl.handle.net/10201/125791
Título: Diagnostic utility of CD205 in breast cancer: Simultaneous detection of myoepithelial cells and dendritic cells in breast tissue by CD205
Autor/es principal/es: Ohe, Rintaro; Aung, Naing Ye; Tamura, Yuka; Kabasawa, Takanobu; Utsunomiya, Aya; Tamazawa, Nobuyuki; Kitaoka, Takumi; Meng, Hong-Xue; Shibata, Kenichi; Yamakawa, Mitsunori
Resumen: Background. CD205 can be used to detect
myoepithelial cells (MECs) and dendritic cells (DCs) in
breast tissue. However, the usefulness of CD205
immunostaining in the pathological diagnosis of breast
tumors is not fully understood. The objective of this
study was to re-evaluate CD205 co-expression with
other MEC markers, such as p63 and CD10, in
nonneoplastic and neoplastic breast tissue and to
evaluate its pathological diagnostic utility in these types
of breast cancer.
Material and methods. Nonneoplastic breast tissue
samples with a terminal duct lobular unit and duct were
obtained from fibroadenoma and mastopathy patients.
Neoplastic breast tissue samples included ductal
carcinoma in situ (DCIS) (n=43) and invasive ductal
carcinoma (IDC) (n=60), including the tubule-forming
type (n=20). These specimens were investigated by
CD205, p63, and CD10 immunostaining.
Results. In addition to p63 and CD10, CD205 was
expressed on MECs in nonneoplastic breast and DCIS
tissue samples; CD205 was simultaneously detected on
DCs that had infiltrated DCIS and IDC tumor nests.
CD205 was expressed on cancer cells themselves in only
7.3% of the breast cancer samples. The number of
intratumoral CD205 + DCs in tubular IDC was
significantly higher than that in DCIS (P<0.01)2020-01-01T00:00:00ZEwing's sarcoma of the cervix: a case report and review of literature.
http://hdl.handle.net/10201/125788
Título: Ewing's sarcoma of the cervix: a case report and review of literature.
Autor/es principal/es: Zhang, Yangyang; Nong, Weixia; Ren, Yan; Jiang, Jinfang; Zhang, Haijun; Meng, Lian; Li, Qianru; Zhang, Qiaochu; Wang, Xiaomeng; Wang, Yang; Liu, Chunxia; Li, Feng
Resumen: Ewing’s sarcoma (ES) is a small cell
malignant tumor that occurs in the bone of children or
adolescents. ES can also occur in extraskeletal organs,
such as the pancreas, thyroid, liver, proximal phalanx,
and, rarely, cervix. Only 15 published case reports have
discussed ES arising in the cervix. We report a 76-year-
old woman who had groin mass. ES was diagnosed in
accordance with morphological and immunohisto-
chemical maps. Fluorescence in situ hybridization and
RT-PCR (reverse transcription PCR) revealed ESWR1
gene rearrangement and fusion gene formation (EWS-
FLI-1), both of which confirmed the diagnosis of ES.
Although the patient underwent surgical resection, the
patient died without chemotherapy and radiotherapy.
This case is the first one to involve a patient aged over
70 years and the fifth one to show metastasis occurrence2020-01-01T00:00:00Z