Digitum Colección:http://hdl.handle.net/10201/177132024-03-28T15:04:52Z2024-03-28T15:04:52ZDifferent effects of neurotensin and neuromedin-N on the proliferative activity of rat adrenal cortexMarkowska, A.Nussdorfer, G.G.Malendowicz, L.K.http://hdl.handle.net/10201/185262020-02-09T00:26:43Z1994-01-01T00:00:00ZTítulo: Different effects of neurotensin and neuromedin-N on the proliferative activity of rat adrenal cortex
Autor/es principal/es: Markowska, A.; Nussdorfer, G.G.; Malendowicz, L.K.
Resumen: Evidence indicates that neurotensin (NT) and
neuromedin-N (NMN) exerts an adrenocorticotropic
effect in the rat. The present study aimed to investigate
whether these neuropeptides are able to stimulate the
proliferation of rat adrenocortical cells in vivo and
to compare their mode of action. Adrenocortical
proliferative activity was assessed by the metaphasearrest
technique and metaphases were counted
per medulla-containing adrenal section. A bolus
administration of NT (3 pglrat) resulted in a significant
increase in the number of metaphases in both zona
fasciculata and the entire cortex, an effect observed 48 h
after the in.jection. The administration of NMN (3 yglrat)
induced a notable rise in the number of metaphases in
the zona fasciculata and the entire cortex within 12 h,
followed by a subsequent drop after 24 h and a return to
normal values at 48 h. These findings indicate that NT
and NMN enhance rat adrenal growth in vivo acting via
different mediators.1994-01-01T00:00:00ZThe contribution of cavernous body biopsy in the diagnosis and treatment of male impotenceMalovrouvas, D.Petraki, C.Constantinidis, E.Petraki, K.Antoniadis, G.Constantinidis, C.Kranidis, A.http://hdl.handle.net/10201/185242020-02-09T00:26:41Z1994-01-01T00:00:00ZTítulo: The contribution of cavernous body biopsy in the diagnosis and treatment of male impotence
Autor/es principal/es: Malovrouvas, D.; Petraki, C.; Constantinidis, E.; Petraki, K.; Antoniadis, G.; Constantinidis, C.; Kranidis, A.
Resumen: This study concerns the results of penile
biopsies in 50 patients aged 27 to 80, with secondary
impotence removed with a biopty gun or during penile
surgery. The biopty gun specimens were equally
representative as the open biopsy ones. The cause and
the degree of erectile dysfunction were determined by
clinical and laboratorial investigation. The histological
study of the cavernous bodies in the patients with
psychogenic impotence revealed normal erectile tissue.
In patients with organic impotence, histological lesions
were graded as mild, moderate or severe. The most
severe lesions were observed in the erectile tissue and in
particular in the smooth muscle of the trabeculae and the
helicine arteries, which had been reduced and replaced
by connective tissue. Histological lesions were found not
only in the arterial but also in the venous leak cases.
There was a correlation between their severity and the
degree of impotence, although of no statistical
significance. The penile biopsy determines the condition
(state) of the functional cavernous smooth muscle tissue,
the integrity of which is essential for the erectile
mechanism as well as for the action of the vasoactive
drugs and the results of vascular surgery. Its important
role is evident as it contributes not only to the diagnosis
of the cause, but also to the choice of treatment of male
impotence.1994-01-01T00:00:00ZRetinal pigment epithelial fine structure in the short-tailed stingray. Dasyatis brevicaudataBraekevelt, Charlie R.http://hdl.handle.net/10201/185252020-02-09T00:26:42Z1994-01-01T00:00:00ZTítulo: Retinal pigment epithelial fine structure in the short-tailed stingray. Dasyatis brevicaudata
Autor/es principal/es: Braekevelt, Charlie R.
Resumen: The retinal pigment epithelium (RPE),
choriocapillaris and Bruch's membrane (complexus
basalis) have been studied by light and electron
microscopy in the short-tailed stingray (Dasyatis
brevicaudata). The RPE consists of a single layer of
cuboidal cells which display numerous basal (choroidal)
infoldings as well as many apical (vitreal) processes
which interdigitate with photoreceptor outer segments.
The lateral cell borders are relatively smooth and joined
by a series of tight junctions. Within these epithelial
cells, smooth endoplasmic reticulum is the dominant
organelle with only scattered profiles of rough
endoplasmic reticulum. Polysosomes, mitochondria and
phagosomes are abundant. Melanosomes are totally
absent over the tapetum and are scarce in non-tapetal
locations. The RPE nucleus is large, vesicular and
centrally located. Rruch's membrane is a pentalaminate
structure. The choriocapillaris is a single layer of large
capillaries. The endothelium of these capillaries is
typically thin but only minimally fenestrated.1994-01-01T00:00:00ZThe pathology of the atrophylhypertrophy complex (AHC) of the liver. A light microscopic and immunohistochemical studyLory, J.Schweizer, W.Blumgart, L.H.Zimmermann, Astridhttp://hdl.handle.net/10201/185232020-02-09T00:26:40Z1994-01-01T00:00:00ZTítulo: The pathology of the atrophylhypertrophy complex (AHC) of the liver. A light microscopic and immunohistochemical study
Autor/es principal/es: Lory, J.; Schweizer, W.; Blumgart, L.H.; Zimmermann, Astrid
Resumen: The term, atrophylhypertrophy complex
(AHC) of the liver, denotes a distinct combination of
hepatic atrophy and hypertrophy occurring in situations
of significant impairment of bile flow andlor portal or
hepatic venous blood flow. In the lobes or segments
concerned atrophy ensues, whereas areas not or less
involved develop compensatory hypertrophy, resulting in
a characteristic gross deformity of the organ and, in
some instances, in rotation of the liver around a virtual
hilar axis. As recognition and early detection of AHC
have a strong implication on the treatment of several
hepatobiliary diseases, adequate combined clinical,
radiological and histopathological strategies have to be
used in order to arrive at a correct diagnosis. The present
investigation was designed to analyze the morphology
of AHC in detail and to define lesion patterns having
the highest predictive value. For atrophy, the following
features were highly characteristic: 1) Advanced septal
fibrosis with or without nodular change of parenchyma;
2) Biliary piecemeal necrosis with formation of vascular
structures; 3) Ductular proliferations, frequently
extending into septa and involving the parenchyma;
4) Capillarization of sinusoids with type IV collagen
deposition in Disse's space; 5) Factor VIII-associated
antigen expression by sinusoidal endothelia; 6) a
seemingly paradoxical increase of proliferative activity
of hepatocytes as based on PCNA staining. The severity
of lesions in atrophy was related to the type of
underlying disease, in that the changes were clearly
more expressed in situations of longstanding obstruction
due to benign disease. Using a set of well-defined
morphological parameters, atrophy can be reproducibly
distinguished from hypertrophy in biopsy material from
AHC.1994-01-01T00:00:00Z