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Título: | Pituitary tumor transforming gene: An important gene in normal cellular functions and tumorigenesis |
Fecha de publicación: | 2007 |
Editorial: | Murcia : F. Hernández |
ISSN: | 0213-3911 |
Materias relacionadas: | 616.2 - Patología del aparato respiratorio |
Palabras clave: | Tumorigenesis Angiogenesis |
Resumen: | Pituitary tumor transforming gene (PTTG) is an oncogene which is found to be highly expressed in proliferating cells and in most of the tumors analyzed to date. Overexpression of PTTG induces cellular transformation and promotes tumor development in nude mice. PTTG is regulated by various growth factors including insulin and IGF-1. PTTG is a multifunctional and multidomain protein. Some of the functions of PTTG include inhibition of separation of sister chromatids, expression and secretion of angiogenic and metastatic factors. In this review we focus on expression of PTTG in normal and tumor tissues, define its biological function, its role in tumorigenesis, and its interaction with other proteins that may play important role in mediating tumorigenic function of PTTG. |
Autor/es principal/es: | Bradshaw, C. Kakar, S.S. |
Forma parte de: | Histology and histopathology |
URI: | http://hdl.handle.net/10201/27549 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 8 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol.22, nº 2 (2007) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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Pituitary tumor transforming gene An important gene in normal cellular functions and tumorigenesis.pdf | 480,79 kB | Adobe PDF | Visualizar/Abrir |
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