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https://doi.org/10.1016/S1885-5857(10)70059-1
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Título: | Characteristics of sudden death in inherited heart disease |
Fecha de publicación: | 17-sep-2009 |
Editorial: | Elsevier |
Cita bibliográfica: | Revista Española de Cardiología; 63(3) 2010: 268-276 |
ISSN: | Electrónico: 1579-2242 Papel: 0300-8932 |
Palabras clave: | Inherited heart disease Cardiomyopathy Channelopathy Sudden death |
Resumen: | Introduction and objectives Cardiomyopathy and channelopathy are major causes of sudden death (SD). The little information available on the context in which SD occurs has come from only a few referral centers. The objective was to investigate the circumstances surrounding SD in families with inherited heart disease.. Methods. The study included 152 SD patients (mean age, 43[19] years) from 103 families. The reasons for inclusion were resuscitated SD in 7%, recent SD in 8%, and a diagnosis of cardiomyopathy or channelopathy in a living relative in 72%. Also, 13% were athletes. Family trees were constructed and each death’s circumstances were recorded. Autopsy and medical records were reviewed. Results. Overall, 18% of SDs occurred during physical exercise, 32% during normal daily activities, and 37% during rest or sleep. There was a significant association between male sex and SD: 111 males (73.0%) versus 41 females (27.0%; P=.03). Exercise-related SD was associated with young age (P=.01). The percentage of SDs associated with exercise, stress, or normal daily activities was significantly greater with cardiomyopathy than channelopathy (61% vs 41%, P=.057). All athletes were male and the majority died during exercise (50% vs 11% of non-athletes; P=.0002). Patients with Brugada syndrome had the highest percentage of SDs during rest or sleep (ie, 47%). No clear trigger could be identified in 33%. Conclusions. SD was common in inherited heart disease, which accounted for a significant number of cases. Males clearly predominated over females (ratio, 3:1) among SD cases (irrespective of pathological type). Most SDs occurred during exercise or normal daily activities in cardiomyopathies and during rest or sleep in channelopathies. The percentage of exercise-related SDs (i.e. 18%) was higher than expected. |
Autor/es principal/es: | Gimeno, Juan Ramón Oliva, María José Lacunza, Javier García Alberola, Arcadio Sabater Molina, María Martínez Sánchez, Juan José Saura, Daniel Romero, Antonio Valdés, Mariano |
Facultad/Departamentos/Servicios: | Facultades, Departamentos, Servicios y Escuelas::Departamentos de la UMU::Ciencias Sociosanitarias |
URI: | http://hdl.handle.net/10201/139283 |
DOI: | https://doi.org/10.1016/S1885-5857(10)70059-1 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 9 |
Derechos: | info:eu-repo/semantics/embargoedAccess |
Descripción: | ©2009. This document is the Accepted, version of a Published Work that appeared in final form in Revista Española de Cardiología. To access the final edited and published work see https://doi.org/10.1016/S1885-5857(10)70059-1 |
Aparece en las colecciones: | Artículos: Ciencias Sociosanitarias |
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