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https://doi.org/10.14670/HH-18-457
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Título: | The PI3K/AKT signaling pathway: How does it regulate development of Sertoli cells and spermatogenic cells? |
Fecha de publicación: | 2022 |
Editorial: | Universidad de Murcia, Departamento de Biologia Celular e Histiologia |
Cita bibliográfica: | Histology and Histopathology Vol. 37, nº7 (2022) |
ISSN: | 0213-3911 1699-5848 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología |
Palabras clave: | PI3K/AKT signaling Sertoli cell Spermatogonia stem cell Blood testis barrier Spermatogenesis |
Resumen: | The PI3K/AKT signaling pathway is one of the most crucial regulatory mechanisms in animal cells, which can mainly regulate proliferation, survival and anti-apoptosis in cell lines. In the seminiferous epithelium, most studies were concentrated on the role of PI3K/AKT signaling in immature Sertoli cells (SCs) and spermatogonia stem cells (SSCs). PI3K/AKT signaling can facilitate the proliferation and antiapoptosis of immature Sertoli cells and spermatogenic cells. Besides, in mature Sertoli cells, this pathway can disintegrate the structure of the blood-testis barrier (BTB) via regulatory protein synthesis and the cytoskeleton of Sertoli cells. All of these effects can directly and indirectly maintain and promote spermatogenesis in male testis. |
Autor/es principal/es: | Chen, Kuang Qi Wei, Bang Hong Hao, Shuang Li Yang, Wan Xi |
URI: | http://hdl.handle.net/10201/128692 |
DOI: | https://doi.org/10.14670/HH-18-457 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 16 |
Derechos: | info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
Aparece en las colecciones: | Vol.37, nº7 (2022) |
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Chen-37-621-636-2022.pdf | 3,94 MB | Adobe PDF | Visualizar/Abrir |
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