Histology and histopathology Vol. 5, nº 2 (1990)
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- PublicationOpen AccessEffects of experimental diabetes in the noradrenergic and cholinergic nerves of the rat small intestine(Murcia: F. Hernández, 1990) Cuervas-Mons, M.; Morte, L.; Junquera, C.; Ramón y Cajal, S.An histochemical research on cholinergic and noradrenergic fibres of the adventitia layer and of the myenteric plexus of the terminal ileum from rats with streptozotocin-induced diabetes, after 20 weeks of evolution of the illness, was carried out to study changes in the innervation of the gut. The cholinergic nerves, revealed through their acetylcholinesterase activity, did not present alterations, but an evident reduction in number of the noradrenergic nerves and swollen intensely fluorescent varicosities, were observed, both in the perivascular and myenteric plexus of terminal ileum from diabetic animals.
- PublicationOpen AccessModification of swine serum-induced bile duct lesion in BALB/c mice by cyclophosphamide(Murcia: F. Hernández, 1990) Doi, K.; Honjo, K.; Doi, C.; Mitsuoka, T.Effects of cyclophosphamide (CY) on the antibody titer level and incidence and severity of swine serum (SS)-induced bile duct lesion (BDL) were examined. BDL induced by 0.2 m1 of SS per head twice a week for 2 weeks was characterized by hyperplasia of biliary epithelial cells, proliferation of mucous glands, and periductal infiltration of eosinophils with mild fibrosis. CY showed no significant influence on the above-mentioned parameters at the dose levels of 140 and 210 mg/kg. On the other hand, CY lowered the antibody titer level and decreased the seventy of BDL at the dose level of 280 mg/kg, and it suppressed the antibody response and BDL at the dose level of 280 X 2 mg/kg. Thus the antibody titer level and the severity of BDL were closely related each other.
- PublicationOpen AccessInfantile cortical hyperostosis (Caffey disease): ultrastructural and immunohistochemical characterization of the peritrabecular cells(Murcia : F. Hernández, 1990) Quacci, Daniela; Pazzaglia, Ugo Ernesto; Dell`Orbo, Carlo; Grazzia Ennas, MaríaThe ultrastructure and the immunohistochemical pattern of the cells which are responsible for the bone resorption in the cortical infantile hyperostosis were investigated. The osteoclasts present a great positivity to MB1 antigen and a low positivity to OKM5. Mononuclear cells with primary lysosomes, looking like osteoclast ones are present in high concentration in peritrabecular spaces. These cells show a high positivity to OKM5 antigen and a low positivity to MB1 antigen. The mononuclear granulated cells are positive to tartrate-resistent acid phosphatase. The possible common origin and their co-operation in bone resorption is discussed.
- PublicationOpen AccessUltrastructural changes in the rat pineal gland after sympathetic denervation. Quantitative study(Murcia : F. Hernández, 1990) Calvo, J.L.; Boya, J.; García-Mauriño, J.E.Ultrastructural changes in the rat pineal gland were studied quantitatively 7 and 60 days after the sympathetic denervation by bilateral excission or decentralization of superior cervical ganglia. The surface occupied by pineal parenchymal cells decreased in rats of experimental groups with respect to the control group. Furthermore, profile areas of the cytoplasm, nucleus and nucleolus of the pinealocytes were also diminished. Cytoplasmic lipid droplets in the pinealocytes were markedly decreased in number and size in experimental rats. As demonstrated by the Kruskal-Wallis H test, statistically significant differences were found between rats of the control and operated groups. Rats treated by superior cervical ganglionectomy or decentralization showed morphological changes indicating a hypofunctional pineal gland, although differences were found between both groups.
- PublicationOpen AccessRetinal photoreceptor fine structure in the mallard duck (Anas platyrhinchos)(Murcia : F. Hernández, 1990) Braekevelt, Charlie R.The retinal photoreceptors of the mallard duck (Anas platyrhynchos) consist of rods, single cones and double (unequal) cones present in a ratio of about 1:2:1. The rods have relatively large cylindrical outer segments which in the light-adapted state reach to the retinal epithelial (RPE) cell bodies and are surrounded by the pigment-laden apical processes of these RPE cells. The inner segment displays an apically located ellipsoid of mitochondria and plentiful polysomes, some rough ER and Golgi zones. The rod nucleus is located within the outer nuclear layer and the synaptic pedicle displays both invaginated (ribbon) and superficial (conventional) synaptic sites. Single cones display a thin tapering outer segment, a large often heterogeneous oil droplet in the apical region of the inner segment, an ellipsoid of mitochondria and a prorninent paraboloid of glycogen. Double cones consist of a larger chief member which shows a thin tapering outer segment, a large heterogeneous oil droplet and a prominent paraboloid. The small accessory cone shows a thin outer segrnent, a small granular oil droplet and a paraboloid. As in the single cone, polysomes, RER and Golgi zones are also present within the inner segment. Near the outer limiting membrane the two members of the double cone show a membrane specialization on their contiguous surfaces. Both single and double cones display severa1 invaginated (ribbon) synapses as well as numerous superficial synaptic sites