Revistas y Congresos

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https://hdl.handle.net/10201/3

Esta comunidad la componen las revistas editadas por la UM y Actas, Jornadas y Congresos organizados por la misma.

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Now showing 1 - 20 of 2011

Open Access
1,25-Dihydroxyvitamin D3 mitigates high glucose-induced oxidative stress, inflammation, and extracellular matrix accumulation in glomerular mesangial cells via the ROS/TXNIP/NLRP3 pathway
(2026) Bo Chen; Chunjiang Zhang; Lin Jia; Xingyu Yao; Gang Liu; Qingyue Meng; Biología Celular e Histología; Universidad de Murcia, Departamento de Biologia Celular e Histiologia
ackground. 1,25-Dihydroxyvitamin D3 (1,25(OH)2D3) is a physiologically active form of vitamin D. Our study investigated the renoprotective functions of 1,25(OH)2D3 in diabetic nephropathy (DN) progression and its underlying mechanism targeting the ROS/TXNIP/NLRP3 inflammasome pathway. Methods. DN was induced in Wistar rats via high-fat diet (4 weeks) and streptozotocin injection (30 mg/kg, i.p.); hyperglycemic rats were randomized into DN and DN + 1,25(OH)2D3 (16 μg/kg, 12 weeks) groups. Rat mesangial HBZY-1 cells were maintained under normal glucose (5.5 mM), high glucose (25 mM), high glucose plus 1,25(OH)2D3 (1-50 nM), or high glucose plus N acetylcysteine (NAC, 10 mM). Cell viability was assessed by the CCK-8 assay. Oxidative stress parameters (ROS via DCFH-DA fluorescence, MDA content, SOD activity) and pyroptosis markers (LDH release, PI/Hoechst 33342 nuclear staining) were quantified. Renal histopathology was performed using PAS and Masson trichrome staining. Biochemical analyses included serum creatinine, urea nitrogen, and 24h urinary protein quantification. Molecular profiling encompassed ELISA (IL-1β, IL-6, TNF-α, IL-18, fibronectin, collagen IV), RT-qPCR (NOX2, NOX4, NLRP3, ASC), western blotting (TXNIP, NLRP3, ASC, caspase-1, IL-1β, IL-18, collagen IV, fibronectin, laminin), and TXNIP immunofluorescence. Results. 1,25(OH)2D3 significantly attenuated high glucose-induced pathological alterations in HBZY-1 cells, including ROS overproduction, TXNIP upregulation, NLRP3 inflammasome activation, oxidative stress, inflammation, extracellular matrix (ECM) deposition, and pyroptotic cell death. Consistently, 1,25(OH)2D3 suppressed ROS/TXNIP/ NLRP3/caspase-1 signaling, ameliorated renal dysfunction, and mitigated histopathological damage in DN rats. Conclusion. 1,25(OH)2D3 confers renoprotection in DN by inhibiting the ROS/TXNIP/NLRP3 inflamma some axis, thereby suppressing oxidative stress, inflammatory cytokine production, ECM accumulation, and pyroptotic cell death in glomerular mesangial cells and renal tissues.
Open Access
11a Bienal de Mercosul: “O Triângulo Atlântico”. Del 6 de abril al 3 de junio de 2018. Porto Alegre, Brasil
(Universidad de Murcia, Servicio de Publicaciones, 2018) Ribero Rueda, Laura; Alcaide Ramírez, Aurora
Bajo el título “El Triángulo Atlántico”, discurre el programa expositivo de la 11ª Bienal de Mercosur en la ciudad de Porto Alegre, al sur de Brasil. Como en todas las ediciones anteriores, hay un curador invitado, que en este caso es el crítico de arte alemán Alfons Hug,1 que cuenta con el apoyo de la joven comisaria de São Paulo, Paula Borghi. En esta edición se reúnen 70 artistas y colectivos que exponen su trabajo en cinco lugares representativos del centro de la ciudad: el Museo de Arte do Rio Grande do Sul - MARGS, el Memorial do Rio Grande do Sul, el centro de arte Santander Cultural, la plaza pública Alfândega y la Iglesia Nossa Senhora das Dores. Como no podría ser de otra manera, los artistas invitados provienen de los tres continentes que integran el “Triángulo Atlántico”: América, África y Europa.
Open Access
1820-1821: Riego mueve Madrid. Nuevas brisas en el viejo repertorio de acción colectiva en la España del siglo XIX
(Servicio de Publicaciones. Universidad de Murcia, 2006) Pinilla Cañadas, Scheherezade; Sin departamento asociado
Partiendo de la idea de repertorio de acción colectiva como producto cultural (Charles Tilly), este artículo centra su atención en las movilizaciones que, en el Madrid de 1820-1821, siguieron a la disolución del Ejército de la Isla y a la destitución de Riego como capitán general de Aragón. Sin negar la pervivencia de las formas tradicionales de protesta, el presente trabajo pretende enriquecer la visión que, generalmente, se tiene de la acción colectiva en la España del siglo XIX, subrayando la aparición de ciertos rasgos que se consideran característicos del nuevo repertorio: la disminución de la violencia, el carácter político de las reivindicaciones, el papel de las Sociedades Patrióticas o la extensión de las movilizaciones.
Open Access
25 años construyendo conocimiento en Psicología del Deporte
(2025) Hernández Mendo, Antonio; Sin departamento asociado
Con la publicación de este tercer y último número de 2025, Cuadernos de Psicología del Deporte culmina un año muy especial en su historia: celebramos nuestro 25º aniversario al servicio de la investigación, la transferencia del conocimiento y la promoción de la Psicología del Deporte como disciplina científica. Un cuarto de siglo de trayectoria editorial nos invita a mirar atrás con orgullo por lo conseguido, pero también a mirar adelante con renovado compromiso hacia los retos que aún tenemos por delante.
Open Access
25 años de investigación histórico-arqueológica en Fortuna. Síntesis bibliográfica
(Universidad de Murcia, Servicio de Publicaciones, 2003) Egea Vivancos, Alejandro
Open Access
40_restos [Reseña. Performance: Homenaje a Tehching Hsieh. Una acción de Domix Garrido (del 4 octubre al 14 noviembre de 2025)].
(Universidad de Murcia, Servicio de Publicaciones., 2026) Vázquez Casillas, José Fernando; Historia del Arte
Open Access
8th INTERNATIONAL SYMPOSIUM ON PERIPHERAL NERVE REGENERATION June 22-24, 2026, Granada, Spain
(2026) Víctor S. Carriel Araya; Biología Celular e Histología; Universidad de Murcia, Departamento de Biologia Celular e Histiologia
Open Access
A pilot study to evaluate the usability of an immersivevirtual reality application for medical training in acute appendicitis.
(Universidad de Murcia, Servicio de Publicaciones, 2025-12-11) Legarreta Gaminde, Asier; Tíscar González, Verónica; Villanueva Ibero, Itsaso; Pérez García, Edorta Ander; Arcaraz Arnaiz, Ane; Alberdi San Román, Igor; Loizate Totaricaguena, Alberto; Alzaga, Iñigo; Sin departamento asociado
Introducción: La realidad virtual (RV) está transformando la educación médica mediantesimulaciones didácticas e interactivas de casos clínicos. La realidad virtual inmersiva (RVI) permiteque el usuario experimente una inmersión total haciéndole creer que se encuentra dentro de eseentorno ficticio. Objetivo: analizar la usabilidad de una aplicación de RVI destinada a la formaciónde estudiantes de medicina en un caso de apendicitis aguda. Metodología. Estudio piloto con 20estudiantes de sexto año medicina. Se ha diseñado un cuestionario para evaluar la usabilidad,aceptabilidad y satisfacción del personal usuario con la tecnología. Se analizaron cada una de lasvariables de forma independiente. Resultados: Todo el personal participante completó lasimulación sin problemas técnicos. Una única persona (5%) manifestó sentir mareos durante lasimulación. Los/as participantes reportaron altos niveles de adaptación al manejo de la tecnología (95%) y comprensión de los paneles e instrucciones de la simulación (100%). Se mostró una granaceptación respecto al uso de esta tecnología para la adquisición de nuevo conocimientos (90%) y eltiempo estimado para asentar conocimientos clínicos con esta intervención (75%). Conclusión: Apesar de que la RVI se encuentre en sus fases iniciales de desarrollo, está generando nuevasoportunidades educativas en la formación médica.
Open Access
A bibliometric insight into sports participation and socio-economic mobility
(Servicio de Publicaciones. Universidad dde Murcia, 2026) Mohapatra, Samapika; Prasad, Sonu; Sinha, Shalu; Sin departamento asociado
Researchers investigated the domain of social mobility and sports (SM&S), analyzing the influence of sports on social mobility and socio-economic factors. This study employed bibliometric analysis to examine previous research on the relationship between sports and social mobility. The objective was to identify unexplored areas by reviewing 582 scholarly papers from WoS published between 1992 and 2023. Geographical mapping displays how research activity is spread out in different regions, while keyword co-occurrence mapping identifies important topics. The research highlighted the exponential growth in the number of documents from 1992 to 2023, particularly after 2003. Geographically, the influence of developed nations was evident in the research. Author co-citation analysis classifies authors into four distinct schools of thought. The results indicate a transition towards a broader and more integrated approach in sports research, emphasising the influence of economics, sociology, wellness, and participation factors. For future research, there is a call for more thematic reviews to delve deeper into the four SM&S thematic strands.
Open Access
A clinicopathological study of eight cases presenting a biphasic structure: A distinct variant of pulmonary carcinoma
(2026) Qiuyao Li; Jiwei Ma; Kun Yang; Xiaoyan Lin; Huifeng Jiang; Yali Xu; Lin Song; Yu Zhang; Xiaoqian Liu; Zheng Mou; Wenjing Su; Hongyu Wang; Biología Celular e Histología; Universidad de Murcia, Departamento de Biologia Celular e Histiologia
Biphasic structures, which are composed of outer basal cells and inner glandular cells, are frequently indicative of salivary gland-type tumors or benign lesions, such as bronchial adenoma, within the lung. However, the occurrence of a biphasic structure in lung cancer is rarely reported and can lead to significant challenges and confusion in diagnosis, particularly in biopsy specimens. In our study, we collected eight lung epithelial tumors that presented with a distinct biphasic structure component and examined their clinicopathological characteristics. Histological examination revealed that the biphasic structure component, often intermingled with conventional squamous cell carcinoma or adeno carcinoma, was defined by basal cells encircling the glandular epithelium. Immunohistochemical analysis demonstrated a distinctive peripheral p40 staining pattern in the biphasic structure component. Genetic analysis identified driver mutations in seven out of eight patients, which are typically associated with conventional pulmonary adenocarcinomas, including EGFR L858R, EGFR 19-del, EGFR 20-ins, and KRAS mutations. The presence of biphasic structure components in these cases confirms a genuine form of lung cancer, likely representing a variant of lung adenocarcinoma. This study's findings enhance the understanding of lung cancer's morphological diversity and caution against prematurely dismissing the malignancy potential of pulmonary epithelial lesions based solely on the presence of basal cells, especially with biopsy specimens.
Open Access
A comprehensive examination of the psychometric properties of the Appearance Anxiety Inventory and its adaptation into Turkish
(Servicio de Publicaciones. Universidad dde Murcia, 2026) Aslan, Emre; Bakalım, Orkide; Taşdelen-Karçkay, Arzu; Sin departamento asociado
Appearance anxiety, characterized by an individual's negative perception of their body image and stress caused by the possibility of their appearance being evaluated by others, can have negative effects on the lives of emerging adults. The aim of this study is to adapt the Appearance Anxiety Inventory (AAI) to Turkish, and also to examine the psychometric properties of the scale comprehensively using classical test theory and some modern measurement approaches. For this purpose, the psychomet ric properties of the AAI in Turkish culture were examined in a sample of emerging adults (N = 520). Confirmatory factor analysis supported the single-factor structure of the AAI. Item response theory analysis revealed that the scale items had sufficient discrimination parameters for levels of appearance anxiety. Network analysis determined that the item with the highest centrality was that regarding the individual hiding or changing his or her appearance. The findings of the study indicate that the AAI has sound psychometric properties that can be used in the assessment of ap pearance anxiety in emerging adults in the Turkish population.
Open Access
A low nuclear-to-cytoplasmic ratio of VDR expression is an independent prognostic marker in breast cancer
(Universidad de Murcia, Departamento de Histología e Histopatología, 2025) Schubert Charlotte; Vilsmaier Theresa; Batz Falk; Cavaillès Vincent; Sixou Sophie; Kolben Thomas; Meister Sarah; Buschmann Christina; Hagemann Friederike; Biología Celular e Histología
The aim of this retrospective study was to analyze the prognostic value of cytoplasmic versus nuclear expression of the vitamin D receptor (VDR) in breast cancer (BC) tissue samples and to relate the results to clinicopathological parameters. VDR expression was assessed in 319 primary breast cancer patients using the Remmele and Stegner immunoreactive scoring (IRS) system. Follow-up data were obtained from the Munich Cancer Registry. The correlation with overall survival (OS) and disease-free survival (DFS) was calculated using univariate and multivariate analyses. Correlation analysis revealed a correlation between nuclear VDR expression and improved outcomes for both OS (p=0.004) and DFS (p=0.001). Conversely, cytoplasmic VDR expression was significantly associated with a shorter OS (p=0.003) and DFS (p<0.001). Additionally, both cytoplasmic and nuclear VDR expression were found to be independent markers of DFS (p<0.001; p=0.021) when examined alongside clinicopathological parameters. Moreover, nuclear VDR expression was positively associated with lower lymph node invasion (pN; p=0.01). For triple-negative patients, cytoplasmic VDR expression was found to have a significant inverse correlation with DFS (p<0.001). Lastly, the ratio of VDR nuclear/cytoplasmic was identified as an auxiliary independent marker of DFS and OS. These findings strongly indicate that the subcellular localization of VDR is crucial in determining BC prognosis. The expression of nuclear VDR appears to have a protective effect, while cytoplasmic VDR is associated with a more aggressive disease course. The data may help identify subgroups of patients with high-risk BC, possibly leading to specific options for targeted tumor therapy
Open Access
A Nau de Pedra
(Universidad de Murcia, Servicio de Publicaciones., 2014) Addas, Claude; Sin departamento asociado
Estes últimos decênios viram multiplicarem-se publicações sobre Ibn ʿArabī e sua escola: traduções e ensaios sucedem-se numa cadência acelerada e a doutrina de Ibn ʿArabī é comentada, analisada, dissecada, com maior ou menor felicidade conforme o caso. É necessário constatar, todavia, que nenhum trabalho de envergadura foi efetuado até aqui sobre a obra poética de Ibn ʿArabī em seu conjunto. Certamente, a partir de 1911, Nicholson publicou em Londres a edição e tradução do Tarğumān al-ašwāq e, mais recentemente, alguns especialistas não temeram aventurar-se no Dīwān de Ibn ʿArabī impresso em Būlāq. Mas, sob o olhar do que resta a decifrar, estas temerárias incursões representam bem pouco. Elas não permitem, de qualquer forma, apreender o lugar eminente que ocupa a poesia na obra de Ibn ʿArabī e menos ainda compreender o papel maior que lhe é atribuído como suporte doutrinal. Não tenho, é claro, a pretensão de preencher esta lacuna; meu propósito é, mais modestamente, fazer uma breve observação acerca desta terra incognita e das riquezas que ela encobre.
Open Access
A new field test for the assessment of upper-body anaerobic power and capacity: from health to sport performance
(Universidad de Murcia: Servicio de Publicaciones, 2026) Miarka, Bianca; da Silva, Valmir; Eizo Nakamura, Eduardo; Fassina Ladeia, Gabriel; Mendes de Oliveira, Fabiano; Andrade, Alexandro; Henrique Magnani Branco, Braulio; Andreato, Leonardo; Sin departamento asociado
This study aimed to develop and determine the concurrent validity of the maximum interval push-up (MIPU) field test to assess upper-body anaerobic power and capacity. For thispurpose, 72 physically active adult men performed either one upper-body Wingate Anaerobic test (WAnT; 30 s all-out) or one MIPU test (6 × 6-s all-out: 10-s recovery). The order of the tests was counterbalanced,with a 30-minute rest interval between them. Pearson's or Spearman's correlation coefficients were calculated to determine the relationships between variables. Inthe comparisons of the absolute values (W) obtained in the WAnT with the results of the MIPU test (rep*kg), a very large correlation was observed for peak power (r=0.75, p<0.001), a large correlation for mean power (r=0.62, p<0.001), and a moderate correlation for minimum power (r=0.27, p=0.021). When comparing the relative values (W/kg) obtained in the WAnT test with those of the MIPU test (rep*kg), large correlations were observed for peak power (r=0.57, p<0.001) and mean power (r=0.50, p<0.001). Thus, MIPU appears to be an easy and practical field test for assessing peak and mean upper-body power in adult men, with potential for use in the sports and health sectors.
Open Access
A New Genesis of Kant’s Essay on the Failure of All Philosophical Trials in Theodicy
(Universidad de Murcia. Servicio de Publicaciones, 2026) Genazzano, Pablo; Sin departamento asociado
Este artículo presenta una nueva géne-sis del ensayo de Kant sobre el fracaso de todos los ensayos filosóficos en teodicea. En primer lugar, explico la razón por la que Kant decidió desacreditar el problema de la teodicea dentro del ámbito del saber filosófico. Tras la reconstrucción del conflicto contemporáneo sobre el ensayo de Kant sobre teodicea, sostengo que la razón de este fracaso reside en el concepto de lo contrario a fin. En segundo lugar, explico los orígenes del neologismo “contrario-a fin” en la obra de Kant. La primera vez que este término fue usado fue en la “Analítica de lo sublime”. Por lo tanto, concluyo que lo sublime sirvió como criterio conceptual para Kant para definir la contrafinalidad del mal en el ensayo sobre el fracaso de la teodicea.
Open Access
A new hybrid of Saxifraga L. (Saxifragaceae)
(Universidad de Murcia. Servicio de Publicaciones, 2025) Lahora, Agustín; Sin departamento asociado
Se describe un nuevo híbrido natural del género Saxifraga L. en la provincia de Almería, Saxifraga ×cuatrecasasii nothosubsp. ivorrae Lahora, nothosubsp. nov. [S. camposii Boiss. & Reut. subsp. leptophylla (Willk.) D.A.Webb × S. erioblasta Boiss. & Reut.] y se tipifica Saxifraga ×cuatrecasasii nothosubsp. cuatrecasasii. Se aporta también información nomenclatural y corológica sobre los parentales y los híbridos.
Open Access
A Note on Plato, Symp. 223b-d.
(Universidad de Murcia, Servicio de Publicaciones., 2025) Broggiato, Maria; Sin departamento asociado
This paper argues that in the final section of Plato’s Symposium (223b-d) we can recognize a deliberate reference to some lines belonging to an elegy of the corpus Theognideum (Theogn. 467-472). This elegy has often been attributed by modern scholars to Evenus of Paros, the sophist and poet who was in contact with Socrates and his circle.
Open Access
A paso firme, para cuarteto de trompas
(InstrumentUM, 2026) Otazo Lozano, Felipe; Sin departamento asociado
Open Access
A pioneering and enlightening doctoral dissertation on medical education: Horsch’s German thesis (1807)
(Universidad de Murcia. Servicio de Publicaciones, 2025) Torralbo Rodríguez, Manuel; Fernández Guerrero, Cristina; Fernández Cano, Antonio; Fernández Guerrero, Inés Mª; Sin departamento asociado
Introduction. This study analyzes a German doctoral thesis entitled Über die Bildung des Arztes als Klinikers und als Staatsdieners (On the Education of Physicians as Clinicians and Civil Servants), defended by Philipp Joseph Horsch (1772-1820) at the University of Würzburg in 1807, possibly the world's first doctoral thesis in the field of medical education. Method. This study is a historiographical and bibliographic review of an academic document, a doctoral dissertation retrieved from the German LEVIVO database. Therefore, it is a documental case study. Results. The academic context and its agents are easily inferable: the University of Würzburg with its associated clinical hospital, the Julius Hospital (Juliusspital) and its medical professors. At the beginning of the 19th century, Europe was immersed in the devastating Napoleonic wars. The text addresses a series of dilemmas related to basic conceptions of medical education, established as dichotomies to be overcome by emphasizing clinical teaching. These dilemmas included: the new versus the old, theory versus practice, medicine as an art versus as a science, hospital versus outpatient medicine, and state physicians versus private ones, which the author does not consider antagonistic, or exclusive, but rather options that can be integrated, synthesized, because they are basically complementary and solvable through hybrid solutions. The author's extensive attention to physicians as civil servants is discussed. In addition, a number of pedagogical recommendations are inferred from the thesis. Discussion. The thesis offers a novel vision of medical education for its time, containing a series of considerations that are still relevant today in the movement of Practical Medicine. Throughout the thesis there are abundant educational recommendations that should not be ignored because they are perennial, in the Leibnizian sense of the term.
Open Access
A redefinition of prognosis: Invasive carcinoma with metastasis originating from microglandular adenosis
(Universidad de Murcia, Departamento de Biologia Celular e Histiologia, 2026) Xiaochun Fei; Dan Chen; Biología Celular e Histología
Aim. To investigate the clinicopathological features, immunophenotype, diagnosis, and prognosis of invasive carcinoma originating from microglandular adenosis. Methods. Two cases of invasive carcinoma originating from microadenosis were analyzed in the Department of Pathology of the Ruijin Hospital affiliated with the Medical College of Shanghai Jiaotong University. Histopathological morphology, immuno-histochemical staining, and prognosis were observed. Results. (1) Histopathological morphology: microscopically, the tumor showed small clusters and nests of infiltrative growth; a few areas showed tubules, and some eosinophilic secretions were observed in the lumen. (2) Immunohistochemistry and molecular genetics: Case 1 was partly positive for S-100, positive for SOX-10, and negative for ER, PR, and HER2 (2+). The result of HER2 gene amplification was negative. Breast and liver tissue lesions in Case 2 were positive for S-100 and SOX-10 but negative for ER and HER2. PR was positive in the liver lesions but showed moderate to strong expression in approximately 80% of the staining. Myoepithelial markers (p63 and calponin) showed loss of myoepithelium around the nests of invasive cancers. TP53 (R213Ter) showed somatic gene variations, and no exon amplification or deletion was detected in BRCA1/2. Conclusion. Invasive carcinoma originating from microadenosis has the same immunophenotype as microadenosis, and its prognosis is difficult to determine.