Browsing by Subject "Therapeutic strategy"

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    Clinical practice guidelines in fibromyalgia. Physiotherapists’ adherence in Denmark: a cross-sectional web-based survey study
    (Springer, 2026-02-18) Fernández Gómez, José Édgar; Gacto Sánchez, Mariano Luis; Oertel Frederiksen, K.; Baño Alcaraz, Aitor; Fisioterapia; Facultades de la UMU::Facultad de Medicina
    Fibromyalgia is a widespread chronic condition. Although Clinical Practice Guidelines for fibromyalgia currently exist, their application in diagnostic and therapeutic settings faces significant implementation challenges across healthcare systems. This has led to a persistent gap between knowledge and clinical practice, a phenomenon yet to be explored in the Danish context. A cross-sectional study was conducted to investigate the level of knowledge and adherence to Clinical Practice Guidelines for fibromyalgia among Danish physical therapists, throughout a questionnaire consisting in the selection of the elements that they would consider for the adequate assessment, treatment, and expected duration of the therapeutic approach, to classify professionals as adherent, partially adherent, or non-adherent based on their selection of assessment and treatment components, and to evaluate their responses to 24 statements on a 5-point Likert scale reflecting their alignment with recommendations from Clinical Practice Guidelines. A total of 149 physiotherapists (mean age 39.26 ± 11.50, and gender-balanced) participated, amongst which 35 (23.49%) were classified as ‘adherent’, and 46 subjects (30.87%) were labelled as ‘partially adherent’ to Clinical Practice Guidelines. Participants’ assessment and therapeutic tools selection was generally aligned with the Clinical Practice Guidelines’ extolled recommendations, except for tender points examination and massage therapy. A number of 14 out of the 24 statements exceeded the predefined 70% agreement threshold. The current study reflects an adequate level of knowledge and adherence amongst physiotherapists in Denmark. Further research and targeted implementation strategies are needed to reduce the evidence-to-practice gap
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    Ferroptosis: A key regulator and potential target for tissue injury
    (Universidad de Murcia, Departamento de Biologia Celular e Histiologia, 2025) Liu, Ruihan; Luo, Qing; Song, Guanbin
    The maintenance of iron homeostasis is essential for proper body function. A growing body of evidence suggests that iron imbalance is the common denominator in many tissue injuries, including acute, chronic, and reperfusion injuries. Ferroptosis, a novel form of programmed cell death due to metabolic abnormalities, has become increasingly recognized as an important process mediating the pathogenesis and progression of numerous tissue injuries, including cerebral, myocardial, lung, liver, kidney, and intestinal injuries. Therefore, a thorough understanding of the mechanisms involved in the regulation of ferroptosis might contribute to improvements in disease management. In this review, we summarize the importance of ferroptosis in various tissue injuries, discuss the potential targets of ferroptosis in the treatment of tissue injuries, and describe the current limitations and future directions of these novel treatment targets