Browsing by Subject "Homogeneous catalysis"

Now showing 1 - 2 of 2
  • Thumbnail Image
    Publication
    Open Access
    Copper-catalysed amination of alkyl iodides enabled by halogen-atom transfer
    (Nature Research, 2021-07-12) Gorski, Bartosz; Barthelemy, Anne-Laure; Douglas, James J.; Juliá Hernández, Fabio; Leonori, Daniele; Química Inorgánica
    Despite the fact that nucleophilic displacement (SN2) of alkyl halides with nitrogen nucleophiles is one of the first reactions introduced in organic chemistry teaching, its practical utilization is largely limited to unhindered (primary) or activated (α-carbonyl, benzylic) substrates. Here, we demonstrate an alternative amination strategy where alkyl iodides are used as radical precursors instead of electrophiles. Use of α-aminoalkyl radicals enables the efficient conversion of the iodides into the corresponding alkyl radical by halogen-atom transfer, while copper catalysis assembles the sp3 C–N bonds at room temperature. The process provides SN2-like programmability, and application in late-stage functionalization of several densely functionalized pharmaceuticals demonstrates its utility in the preparation of valuable N-alkylated drug analogues.
  • Thumbnail Image
    Publication
    Open Access
    Transition-metal-catalyzed carboxylation reactions with carbon dioxide
    (Wiley, Gesellschaft Deutscher Chemiker, 2018-03-03) Tortajada, Andreu; Juliá Hernández, Francisco; Börjesson, Marino; Moragas, Toni; Martin, Ruben; Química Inorgánica