Browsing by Subject "Emotional memory"
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- PublicationEmbargoEffects of stress on emotional memory in patients with Alzheimer’s disease and in healthy elderly(Cambridge University Press, 2017-12-14) Gómez Gallego, María; Gómez García, Juan; Atención SociosanitariaObjective: We aimed at examining the relation between stress markers (cortisol levels and state anxiety) with memory for emotional information in AD patients and in healthy elderly. Design, Setting, and participants: Baseline and changes in stress markers during memory testing were assessed in a sample of 98 elderly (46 mild-to-moderate Alzheimer’s disease patients and 52 controls) recruited from dementia day centers and adult day centers, respectively. Measurements: Salivary cortisol, state anxiety, and measures of immediate recall and delayed recognition using the International Affective Pictures System. Results: Patients’ performance in memory tasks was not associated with either cortisol levels or anxiety. In controls, quadratic and linear associations were found between cortisol and immediate recall scores (total and bias, respectively). Besides, quadratic and linear associations were observed between anxiety and delayed recognition scores (total and bias, respectively). Conclusions: The emotional memory of patients with Alzheimer´s disease is not related to stress markers as healthy older adults’ is. Future studies that include moderating variables are needed to explain the lack of association.
- PublicationEmbargoEffects of stress on emotional memory in patients with Alzheimer’s disease and in healthy elderly(Cambridge University Press, 2017-12-14) Gómez Gallego, María; Gómez García, Juan; Métodos Cuantitativos para la Economía y la EmpresaObjective: We aimed at examining the relation between stress markers (cortisol levels and state anxiety) with memory for emotional information in AD patients and in healthy elderly. Design, Setting, and participants: Baseline and changes in stress markers during memory testing were assessed in a sample of 98 elderly (46 mild-to-moderate Alzheimer’s disease patients and 52 controls) recruited from dementia day centers and adult day centers, respectively. Measurements: Salivary cortisol, state anxiety, and measures of immediate recall and delayed recognition using the International Affective Pictures System. Results: Patients’ performance in memory tasks was not associated with either cortisol levels or anxiety. In controls, quadratic and linear associations were found between cortisol and immediate recall scores (total and bias, respectively). Besides, quadratic and linear associations were observed between anxiety and delayed recognition scores (total and bias, respectively). Conclusions: The emotional memory of patients with Alzheimer´s disease is not related to stress markers as healthy older adults’ is. Future studies that include moderating variables are needed to explain the lack of association.
- PublicationOpen AccessRats conserve passive avoidance retention level throughout the light phase of diurnal cycle.(Elsevier, 2023-05-10) Morales-Delgado, Nicanor; Popovic, Natalija; Cruz Sánchez, Ernesto de la; Popovic Popovic, Miroljub; Anatomía Humana y PsicobiologíaEmotions and memory formation are sensible to circadian rhythm. Here we study whether the time of day during the light phase of the diurnal cycle affects emotional memory in male Wistar rats using the passive avoidance (PA) test. Experiments were conducted at the beginning of Zeitgeber time (ZT) (ZT0.5-2), mid-time (ZT5-6.5), and end (ZT10.5-12) of the light period. Our results suggest that time of day has no impact on emotional response during acquisition trials, but slightly influences cognitive response during the 24-hour retention trial. Retention response was highest for ZT5-6.5, followed by ZT0.5-2, and lowest for ZT10.5-12.
- PublicationEmbargoTime course of scopolamine effect on memory consolidation and forgetting in rats(Elsevier, 2014-11-18) Popovic, Miroljub; Giménez de Béjar, Verónica; Popovic, Natalija; Caballero Bleda, María; Anatomía Humana y PsicobiologíaThe effect of scopolamine on the consolidation and forgetting of emotional memory has not been completely elucidated yet. The aim of the present study was to investigate the time course of scopolamine effect on consolidation and forgetting of passive avoidance response. In a first experiment of the present study, we tested the effect of scopolamine (1mg/kg, i.p., immediately after acquisition), on 24h and 48h retention performance of the step-through passive avoidance task, in adult male Wistar rats. On the 24h retested trial, the latency of the passive avoidance response was significantly lower, while on the 48h retested trial it was significantly higher in scopolamine than in the saline-treated group. In a second experiment, we assessed the 24h time course of scopolamine (1mg/kg) effect on memory consolidation in passive avoidance task. We found that scopolamine administration only within the first six and half hours after acquisition improved memory consolidation in 48h retention performance. Finally, a third experiment was performed on the saline- and scopolamine-treated rats (given immediately after acquisition) that on the 48h retention test did not step through into the dark compartment during the cut-off time. These animals were retested weekly for up to first three months, and after that, every three months until the end of experiment (i.e., 15 months after acquisition). The passive avoidance response in the saline treated group lasted up to 6 weeks after acquisition, while in the scopolamine treated group 50% of animals conserved the initial level of passive avoidance response until the experiment end point. In conclusion, the present data suggest that (1) improving or impairment effect of scopolamine given in post-training periods depends on delay of retention trial, (2) memory consolidation process could be modify by scopolamine within first six and half hours after training and (3) scopolamine could delay forgetting of emotional memory.