Browsing by Subject "Club cells"

Now showing 1 - 2 of 2
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    Adrenomedullin regulates club cell recovery following lung epithelial injury
    (Universidad de Murcia. Departamento de Biología Celular e Histología, 2016) García-Sanmartín, Josune; Larrayoz, Ignacio M.; Martínez, Alfredo
    The equilibrium between lung epithelium damage and recovery in the context of chronic injury is at the basis of numerous lung diseases, including lung cancer and COPD. Understanding the contribution of growth factors and other molecular intermediates to this crosstalk may help in devising new therapeutic approaches. To better understand the contribution of adrenomedullin (AM) to lung homeostasis, we built club cell-specific conditional knockout (KO) mice for AM and subjected them to naphthalene injury. Untreated KO mice had lower levels of club cell 10 KDa protein (CC10) immunoreactivity than their wild type (WT) littermates in both terminal and regular bronchioles. Naphthalene injury resulted in a rapid necrosis of club cells followed by a progressive recovery of the epithelium. Club cells proliferated at higher rates in the KO mice and at 21 days post-injury the club cell coverage of the main bronchioles was higher and more homogeneous than in the WT animals. In conclusion, the paracrine/autocrine influence of AM in club cells subtly modulates their proliferation and spreading kinetics during lung epithelium recovery.
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    Club (Clara) cells in human prostate: A survival guide for conventional histologists/histopathologists
    (2026) Albena Fakirova; Boryana Ilcheva; Maria Koleva; Dorian Dikov; Biología Celular e Histología; Universidad de Murcia, Departamento de Biologia Celular e Histiologia
    Broncho-pulmonary club (Clara) cells (Cc) play a protective role in the lung due to the secretion of the CC16 protein. Their normal and pathological morphology and function have long been well characterized by histologists and histopathologists. In recent years, human prostatic Cc have become the focus of intensified research. A three-dimensional cellular atlas of normal and pathologic human and experimental prostates has been developed using the most advanced research methods (single-cell RNA sequencing, RNA in situ). This review provides a comprehensive synthesis of current knowledge regarding prostatic Cc and Cc phenotype conversion across prostate disease. Prostatic Cc possesses anti-inflammatory, regenerative, and immunoregulatory potential, and exhibits features like those of their pulmonary counterparts. Their ontogenesis, localization across different prostatic zones, gene expression profile, and histo-functional morphology are discussed and illustrated immunohistochemically using original material from the authors. Pathophysiological and morphogenetic considerations are also presented.