Browsing by Subject "Benznidazole"

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    Anticipating the side effects of benznidazole: HLA-B*35 and patch test
    (Elsevier, 2024-04-14) Vázquez, Cristina; García-Vázquez, Elisa; Carrilero, Bartolomé; Muro, Manuel; Sánchez-Guerrero, Inmaculada; González López, Rosana; Franco, Fuensanta; Segovia, Manuel; Medicina
    ABSTRACT: Introduction: Treatment of Chagas disease frequently causes distress to patients due to a high incidence of adverse effects. Different preemptive tests have been researched to prevent these effects and to allow focus to be given to certain predisposed patients. Benznidazole is the most prescribed Chagas disease treatment in Spain. In this work, we analyzed the genetic markers HLA-B*35 allele group and HLA-B*35:05 allele specifically, as well as an allergy patch test, as benznidazole’s most frequent adverse effects are cutaneous. Methods: HLA-B intermediate-resolution genotyping was performed followed by a high-resolution level analysis. Cutaneous allergies were tested using strips impregnated with a mixture of benznidazole and placed on the upper back of patients before starting treatment. Results: In our sample of more than 400 patients, there was almost no relationship between any kind of side effect and either of the HLA-B alleles studied. The patch testing was quickly discarded as a preemptive test due to its low sensitivity (16.7%). Conclusion: In conclusion, we were unable to replicate and corroborate genetic markers identified by other groups and there is currently no test that can anticipate the adverse effects of benznidazole, therefore, more investigation should be carried out in this field.
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    Tolerance and adherence of patients with chronic chagas disease treated with benznidazole
    (Sociedade Brasileira de Medicina Tropical, 2023) Vázquez, Cristina; García-Vázquez, Elisa; Carrilero, Bartolomé; Simón, Marina; Franco, Fuensanta; Iborra, María Asunción; Gil-Gallardo, Luis Javier; Segovia, Manuel; Medicina
    Background: Chagas disease (CD) treatment is commonly associated with a high incidence of adverse effects. It is crucial to study and update these adverse effects to improve the existing knowledge of which drugs to use and to clarify the information presented to patients. Methods: We analyzed the adverse effects of benznidazole in two cohorts of patients: a large retrospective study and a small prospective study. Results: This large retrospective study described the most and least common adverse effects in our area and characterized our Chagas disease population. This prospective study, along with a close follow-up of the treatment, detected more adverse effects and enhanced the patients’ perception of the disease and treatment. Conclusions: This information is important for preventing non-medical-related withdrawals and for removing baseless fears. Better knowledge of patients could help us provide better care.