Browsing by Subject "Barrett's esophagus"

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    Case report, esophageal collision tumor (oat cell carcinoma and adenocarcinoma) in Barrett´s esophagus: immunohistochemical, electron microscopy and LOH analysis
    (Murcia : F. Hernández, 2003) González, L.M.; Sanz Esponera, J.; Saez, C.; Alvarez, T.; Sierra, E.; Sanz Ortega, J.
    We report a case of an esophageal collision tumor composed of adenocarcinoma and oat cell carcinoma. Both tumors appeared to arise from dysplastic Barrett's mucosae in a 75-year-old man. Immunohistochemical stains and electron microscopy demonstrated a separate identity for each of the tumors in collision. Molecular analysis of microsatellite regions was performed in different microdissected areas. Identical loss of heterozygosity (LOH) at 9p21 and 17p13 was determined in the three different microdissected areas of the adenocarcinoma component. LOH was not determined in any area of the oat cell carcinoma. This is the first study that analyzes the allele status of an esophageal collision tumor. Our findings suggest a biclonal origin for both components of the collision tumor.
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    Helicobacter pylori in Barrett's esophagus
    (Murcia : F. Hernández, 1991) Ferreres, Joan-Carles; Fernández, Fidel; Rodríguez Vives, Agustín; González-Rodilla, Irene; Ursúa, Inmaculada; Ramos, Rafael; Val-Bernal, José Fernando
    Barrett's esophagus is an anatomicoclinical state in which, due to the prolonged action of gastroesophageal reflux, the squamous epithelium is replaced by columnar epithelium. Helicobacter pylori has been implicated in the pathogenesis of various gastrointestinal disorders and has occasionally been observed in Barrett's esophagus. The aim of this study is to determine the incidence of H. pylori in Barrett's esophagus and try to establish its role in the pathogenesis of this disorder. H. pylori was observed in 31 biopsies (44.3%) of the 70 studied, mainly when the epithelium is of the gastric atrophic-fundic type (p < 0.01). Its presence shows no relation to the degree of inflammatory activity and does not seem, therefore, to play an important role in the pathogenesis of the lesion.