DigitalUM :: Browsing by Subject "Alzheimer’s disease"

Browsing by Subject "Alzheimer’s disease"

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Open Access
A corpus analysis of the aktionsarten of English-speaking patients with Alzheimer’s disease : a role and reference grammar account.
(Universidad de Murcia, Servicio de Publicaciones., 2024) Suárez Rodríguez, Alejandro
In this paper, we aim to describe the frequency and relative distribution of verb use by English-speaking patients with Alzheimer’s disease along its three stages. To do so, we apply the semantic representation of Role and Reference Grammar by means of the lexical aspect or Aktionsart to samples of verbs taken from the Pitt corpus of American patients with Alzheimer’s disease. Then we apply descriptive statistical measures and hypothesis testing to the samples. Our results show that patients systematically use states as the preferred type of verbs in the three stages when compared to the rest of Aktionsarten. We also show that there exists a statistically significant relation between the lexical aspect of verbs and the stages of Alzheimer’s disease. Among the explanations for these results, we propose that states may be used as the default Aktionsart because of its easier cognitive processing.
Open Access
A Prototype for the Voice Analysis Diagnosis of Alzheimer’s Disease
(IOS Press, 2018-04-26) Martínez-Sánchez, Francisco; García Meilán, Juan José; Carro, Juan; Ivanova, Olga; Psicología Básica y Metodología
Background: Speech variations enable us to map the performance of cognitive processes of syntactic, semantic, phonological, and articulatory planning and execution. Speaking is one of the first functions to be affected by neurodegenerative complaints such as Alzheimer’s disease (AD), which makes the speech a highly promising biomarker for detecting the illness before the first preclinical symptoms appear. Objective: This paper has sought to develop and validate a technological prototype that adopts an automated approach to speech analysis among older people. Methods: It uses a mathematical algorithm based on certain discriminatory variables to estimate the probability of developing AD. Results and Conclusion: This device may be used at a preclinical stage by non-expert health professionals to determine the likelihood of the onset of AD.
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Age-related brain pathology in Octodon degu: blood vessel, white matter and Alzheimer-like pathology
(Elsevier, 2009-11-11) Van Groen, Thomas; Kadish, Inga; Caballero Bleda, María; Baño-Otalora, Beatriz; Vivanco, Pablo; Rol, María Ángeles; Madrid, Juan Antonio; Popovic, Natalija; Popovic Popovic, Miroljub; Anatomía Humana y Psicobiología
Recently it has been shown that over 3-year-old wild-type South American rodents, Octodon degus, the "common degu" or degu, of their own accord develop Alzheimer's disease neuropathological hallmarks: amyloid-β-peptide depositions and accumulation of tau-protein. Here we analyzed brains of 1-, 3- and 6-year-old degu's, bred in standard animal facilities. Significant amounts of Aβ and tau deposits are present in the hippocampal formation of 6-year-old O. degus, primarily in the white matter, but these hippocampal Aβ and tau deposits are not present in younger ones. In contrast, significant Aβ deposits in blood vessel walls are already found in 3-year-old animals. The tau deposits in the hippocampal formation coincide with a significant decrease in staining for myelin in the same areas, indicating hippocampal disconnection and, likely, dysfunction. Our findings indicate that (1) cerebral amyloid angiopathy precedes brain parenchyma pathology in aged degu's and (2) the onset of disease seems to be delayed in the laboratory vs. wild-type degu's.
Open Access
Aluminium exposure induces Alzheimer s disease-like histopathological alterations in mouse brain
(Murcia : F. Hernández, 2008) Rodella, L.F.; Ricci, F.; Borsani, E.; Stacchiotti, A.; Foglio, E.; Favero, G.; Rezzani, R.; Mariani, C.; Bianchi, R.
Aluminium (Al) is a neurotoxic metal and Al exposure may be a factor in the aetiology of various neurodegenerative diseases such as Alzheimer’s disease (AD). The major pathohistological findings in the AD brain are the presence of neuritic plaques containing ßamyloid (Aß) which may interfere with neuronal communication. Moreover, it has been observed that GRP78, a stress-response protein induced by conditions that adversely affect endoplasmic reticulum (ER) function, is reduced in the brain of AD patients. In this study, we investigated the correlation between the expression of Aß and GRP78 in the brain cortex of mice chronically treated with aluminium sulphate. Chronic exposure over 12 months to aluminium sulphate in drinking water resulted in deposition of Aß similar to that seen in congophilic amyloid angiopathy (CAA) in humans and a reduction in neuronal expression of GRP78 similar to what has previously been observed in Alzheimer’s disease. So, we hypothesise that chronic Al administration is responsible for oxidative cell damage that interferes with ER functions inducing Aß accumulation and neurodegenerative damage.
Open Access
APP transgenic mice and their application to drug discovery
(F. Hernández y J.F. Madrid. Murcia: Universidad de Murcia, Departamento de Biología Celular e Histología., 2011) Howlett, D.R.
The development of transgenic mice expressing mutated forms of the human amyloid precursor protein (APP) and presenilin-1 (PS1), proteins associated with familial forms of Alzheimer’s disease (AD), has provided a backbone for translational studies of potential novel drug therapies. Such mice model some aspects of AD pathology in that they develop senile plaque-like deposits of the amyloid beta-protein (Aß) together with inflammatory pathology and some degree of neurodegeneration. Aß deposition is considered to be a potentially pathogenic feature of AD and drug discovery programmes utilising such mice and associated with drugs now reaching the clinic have been largely directed towards decreasing the deposition. This goal has been achieved in the mouse models, although the agents developed have not, to date, shown evidence of efficacy in AD sufferers and, in some cases, have worsened the clinical state. Nevertheless, reducing the pathological features of the disease continues to be the objective of pharmacological intervention and ongoing programmes continue to use transgenic mice expressing mutated APP and PS1 transgenes in attempts to overcome issues and difficulties arising from the initial clinical trials and to explore new approaches to AD treatment.
Open Access
Coexistence of reactive plasticity and neurodegeneration in Alzheimer diseased brains
(Murcia : F. Hernández, 2004) Guevara, J.; Dilhuydy, H.; Espinosa, B.; Delacourte, A.; Quirion, R.; Mena, R.; Joanette, Y.; Zenteno, E.; Robitaille, Y.
Alzheimer’s disease (AD) is a pathological process characterized by neuron degeneration and, as recently suggested, brain plasticity. In this work, we compared the reactive plasticity in AD brains associated to O-glycosydically linked glycans, recognized by lectins from Amaranthus leucocarpus (ALL) and Macrobrachium rosenbergii (MRL), and the tau neuritic degeneration. The neuritic degenerative process was evaluated by the quantification of aggregated neuritic structures. Lesions were determined using antibodies against hyperphosphorylated-tau (AD2), amyloid-ß, and synaptophysin. In these conditions, we classified and quantified three pathological structures associated to the neuritic degenerative process: 1) Amyloid-ß deposits (AßDs), 2) Classic neuritic plaques (NPs), and 3) Dystrophic neurites clusters (DNCs) lacking amyloid-ß deposits. Reactive plasticity structures were constituted by meganeuritic clusters (MCs) and peri-neuronal sprouting in neurons of the CA4 region of the hippocampus, immunoreactive to synaptophysin (exclusively in AD brains) and GAP-43. Besides, MCs were associated to sialylated O-glycosydically linked glycans as determined by positive labeling with ALL and MRL. Considering that these lectins are specific for the synaptic sprouting process in AD, our results suggest the co-occurrence of of several areas of reactive plasticity and neuron degeneration in AD.
Open Access
Comparative efficacy of active group music intervention versus group music listening in Alzheimer’s disease
(MDPI, 2021-07-30) Gómez Gallego, Juan Cándido; Gallego Mellado, María; García García, Javier; Gómez Gallego, María; Economía Aplicada
Open Access
Comparison of MR images and histochemical localization of intra-arterially administered microglia surrounding ß-amyloid deposits in the rat brain
(Murcia : F. Hernández, 2006) Song, Y.; Morikawa, S.; Morita, M.; Inubushi, T.; Takada, T.; Torii, R.; Kitamura, Y.; Taniguchi, T.; Tooyama, I.
The therapeutic use of microglial cells has recently received some attention for the treatment of Alzheimer disease (AD), but few non-invasive techniques exist for monitoring the cells after administration. Here we present a magnetic resonance imaging (MRI) technique for tracking microglia injected intra-arterially in vivo. We micro-injected Aß42 into the left hippocampus and saline into the right hippocampus of rats. We then administered microglia, which were labeled with enhanced green fluorescent protein (EGFP) gene and Resovist, into the carotid artery. After monitoring exogenously administered microglia using MRI, we compared the MR images and the histochemical localization of administered microglia. MRI revealed clear signal changes attributable to Resovist-containing microglia in Aß-injected areas. Histochemistry demonstrated that EGFP-positive microglia accumulated around Aß deposits and internalized the peptide. This study demonstrates the usefulness of MRI for non-invasive monitoring of exogenous microglia, and suggests a promising future for microglia/macrophages as therapeutic tools for AD.
Open Access
Cytoplasmic inclusions of TDP-43 in neurodegenerative diseases: A potential role for caspases
(Murcia : F. Hernández, 2009) Rohn, Troy T.
TAR DNA-binding protein-43 (TDP-43) proteinopathies are classified based upon the extent of modified TDP-43 inclusions and include a growing number of neurodegenerative diseases including amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration with ubiquitin immunoreactive, tau negative inclusions (FTLD-U) and FTLD with motor neuron disease (FTLD-MND). In addition, TDP-43 inclusions have also been identified in a number of other neurodegenerative disorders including Alzheimer’s disease, corticobasal degeneration, Lewy body related diseases and Pick’s disease. Current understanding suggests that in these diseases, TDP-43 is relocated from the nucleus to the cytoplasm and sequestered into inclusions that contain modified TDP-43. Major modifications of TDP-43 have been identified as being hyperphosphorylation and proteolytic cleavage by caspases. In this review a summary of the major findings regarding the proteolytic modification of TDP-43 will be discussed as well as potential toxic-gain mechanisms these fragments may cause including cytoskeletal disruptions.
Open Access
Discriminating speech traits of Alzheimer’s disease assessed through a corpus of reading task for Spanish language
(2021-12-05) Ivanova, Olga; García Meilán, Juan José; Martínez-Sánchez, Francisco; Martínez-Nicolás, Israel; Llorente, Thide; Carcabilla-Gonzalez, Nuria; Psicología Básica y Metodología
It is estimated that between 50% and 75% of all cases of dementia are due to Alzheimer’s disease (AD), the most common neurodegenerative disease among World population. However, a long preclinical period of AD makes it difficult to differentiate between people with Mild Cognitive Impairment (MCI) that would progress to dementia from people with MCI that would not. One of the most promising solutions to detect MCI which will evolve to dementia (preAD) comes from the field of automatic speech analysis. Speech is a complex physiological and neurocognitive language-mediated process, which can be significantly altered in pathological aging and exhibit high levels of sensitivity for the diagnosis of neurological diseases. The purpose of this research is to offer a detailed perspective on the speech changes in MCI and mild AD when compared to healthy aging (HA), that would allow to detect pathological processes prior to the clinical expression of AD. Based on our previous research record on speech in HA, MCI and AD, we provide a global review of dementia-related speech traits and propose a reading-based protocol for assessing ongoing neurodegenerative processes in the elderly. We report the results of speech analysis in elderly people with different cognitive profiles, who performed a standardized reading task and were further analyzed for correlations between neurocognitive assessment indicative of cognitive impairment stage (HA, MCI or AD) and acoustic, temporal and prosodic traits in speech. We show that evolution from HA to AD exhibits a steady pattern of speech changes in parallel to the cognitive decline, which consists in significant increase in duration and phonation time, extension of pauses and voice breaks, intensification of variation in syllabic production, and decrease in speech energy and intensity leading to dysphony. In doing so, we prove that a standardized reading task is a very useful type of stimuli for detecting dementia-related speech traits and, in view of this, we discuss the relevance of reading for preclinical automated diagnosis of AD. The main contribution of this paper is a corpus of recordings of the standardized reading task performed by healthy elderly people and people with MCI and AD in Spanish language, and which can be used for further research purposes. In this respect, our work fills an important gap existing in corpora-based studies of speech and language impairments related to progression to dementia.
Open Access
Disruption of brain zinc homeostasis promotes the pathophysiological progress of Alzheimer's disease
(Universidad de Murcia. Departamento de Biología Celular e Histología, 2016) Li, Lin-Bo; Wang, Zhan-You
Zinc is abundant in the brain, where it plays an important role in synaptic plasticity and in learning; however, excessive zinc is toxic to neuronal cells, and dyshomeostasis of zinc in the brain is a contributing factor for Alzheimer’s disease (AD). Deposition of zinc has been detected in senile plaques in the form of zincAβ (β-amyloid) complexes. Recent studies have demonstrated that zinc exposure to the brain enhances βamyloid precursor protein (APP) expression, amyloidogenic APP cleavage and plaque burden. Furthermore, alterations in zinc transporters, which are responsible for zinc homeostasis, occur in AD human brain and transgenic mouse models. These suggest that abnormal brain zinc homeostasis is involved in the pathophysiological progress of AD.
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Effects of stress on emotional memory in patients with Alzheimer’s disease and in healthy elderly
(Cambridge University Press, 2017-12-14) Gómez García, Juan; Gómez Gallego, María; Métodos Cuantitativos para la Economía y la Empresa
Objective: We aimed at examining the relation between stress markers (cortisol levels and state anxiety) with memory for emotional information in AD patients and in healthy elderly. Design, Setting, and participants: Baseline and changes in stress markers during memory testing were assessed in a sample of 98 elderly (46 mild-to-moderate Alzheimer’s disease patients and 52 controls) recruited from dementia day centers and adult day centers, respectively. Measurements: Salivary cortisol, state anxiety, and measures of immediate recall and delayed recognition using the International Affective Pictures System. Results: Patients’ performance in memory tasks was not associated with either cortisol levels or anxiety. In controls, quadratic and linear associations were found between cortisol and immediate recall scores (total and bias, respectively). Besides, quadratic and linear associations were observed between anxiety and delayed recognition scores (total and bias, respectively). Conclusions: The emotional memory of patients with Alzheimer´s disease is not related to stress markers as healthy older adults’ is. Future studies that include moderating variables are needed to explain the lack of association.
Open Access
¿Hasta dónde llega la precocidad de la tomografía de coherencia óptica en el deterioro cognitivo?
(Viguera editores, 2016-07-01) Giménez Castejón, Domingo; Martínez Martínez, María de los LLanos; Dudekova, Mirka; Lajara Blesa, Jerónimo; Gómez Gallego, María; Atención Sociosanitaria
Introducción. La enfermedad de Alzheimer (EA) es la primera causa de demencia mundial. Cada vez son más los esfuerzos para lograr una detección temprana del deterioro cognitivo y surgen en el panorama científico entidades diagnósticas como el deterioro cognitivo leve (DCL) y las quejas subjetivas de memoria (QSM). Debido a ello, aparecen numerosos biomarcadores estudiados para conseguir dicho objetivo, entre ellos la tomografía de coherencia óptica. Sujetos y métodos. Se ha realizado un estudio que utiliza la tomografía de coherencia óptica para medir el grosor macular y la capa de fibras nerviosas de la retina en pacientes diagnosticados de EA (n = 36), pacientes con DCL (n = 33), en individuos con QSM (n = 24) y en sujetos control (n = 45). Resultados. Se han encontrado diferencias estadísticamente significativas en cuanto al grosor macular entre todos los grupos estudiados (QSM: 261,8 ± 25,88 μm; DCL: 259,19 ± 22,582 μm; EA leve: 258,53 ± 14,804 μm; EA moderada: 249,32 ± 18,467 μm) y sujetos control (271,96 ± 15,57 μm). Respecto a la capa de fibras nerviosas de la retina, ocurre de igual manera, y la diferencia es estadísticamente significativa frente al grupo control (94,51 ± 9,203 μm) de todos los grupos (QSM: 90,44 ± 9,059 μm; DCL: 89,4 ± 10,421 μm; EA leve: 87,12 ± 10,279 μm; EA moderada: 82,25 ± 10,636 μm). Conclusión. La tomografía de coherencia óptica podría situarse como un futuro biomarcador y una herramienta de apoyo para facilitar el diagnóstico precoz del deterioro cognitivo y de la EA.
Open Access
Histopathological evaluation of insulin-DMSO formula designed for direct nose-to-brain delivery
(Universidad de Murcia, Departamento de Biologia Celular e Histiologia, 2022) Maher, Mustafa A.; Kandeel, Wafaa A.; Hammam, Olfat A.; Attia, Yasmeen M.; Mahmoud, Soheir; Salah, Mohamed
The combination of insulin and DMSO is a patented (Publication No US8987199B2), noninvasive, pharmaceutically strategized preparation for direct noseto-brain delivery (DN2BD) suggested for the treatment of Alzheimer’s disease (AD). Although its main ingredients have been individually researched, no histopathological investigations have been conducted to address this combination effect on the CNS and nasal tissues in animals. The present work was, therefore, designed to investigate the potential histopathological changes induced by this new pharmaceutical combination using a newly developed refractory staining method. The findings presented herein showed no signs of treatment-related lesions or behavioral changes in Sprague Dawley rats following a three-month successive treatment with two strengths of the formula.
Open Access
La interpretación artística para la investigación y el abordaje no farmacológico en la enfermedad de Alzheimer
García Aranda, Victoria Sara; Arnardóttir, Halldóra; Salmerón Aroca, Juan Antonio; Educación
Hoy en día más de 35 millones de personas padecen demencia a nivel mundial, constituyendo la causa más común la enfermedad de Alzheimer. La persona diagnosticada de esta enfermedad cerebral presenta, además de un deterioro de la memoria, dificultades para reconocer y expresar sus emociones, por lo que precisa estímulos identificativos de las mismas; en este sentido, el arte visual supone un medio de acceso a dichas emociones, ya que puede actuar como dicho estímulo. Este trabajo se basa en las diferentes investigaciones en torno al abordaje no farmacológico de la enfermedad del Alzheimer que demuestran que el tratamiento con las diferentes manifestaciones artísticas contribuyen a mejorar algunos aspectos de la enfermedad de Alzheimer, como el acceso a los recuerdos. Partiendo de esta base, este estudio tiene como objeto mejorar la calidad de vida del paciente de Alzheimer y sus familiares, trabajando las emociones y la expresión de las mismas a través de ejercicios conductuales de origen artístico-interpretativo en el entorno museístico, con el fin de establecer canales comunicativos alternativos a las vías de interacción hasta el momento existentes entre el paciente y su cuidador. Para llevarlo a cabo se trabajó con un grupo de siete personas diagnosticadas de enfermedad de Alzheimer en GDS 4 (grado 4 en la Escala de Deterioro Global de Reisberg). El criterio de selección de la muestra fue incidental e intencional y obedece tanto a la disponibilidad de los pacientes como a las características que el aspecto emocional conlleva en el estadio 4 de la enfermedad: el deterioro cognitivo y emocional consecuente es patente aunque no inabordable. En cada sesión se trabajó con la visualización de una obra de arte como punto de partida, preguntas abiertas para dar lugar a rememorar historias personales y la realización de una partitura de movimiento. Pese a las limitaciones que pueda tener este estudio, contribuye a abrir nuevas vías para conocer el estado emocional de las personas que sufren la enfermedad de Alzheimer (GDS 4) después de emplear la técnica de la partitura de movimientos en el entorno museístico.
Open Access
Melanopsin-expressing retinal ganglion cells in aging and disease.
(Universidad de Murcia, Departamento de Biologia Celular e Histiologia, 2019) Esquiva, Gema; Hannibal, Jens
Melanopsin-expressing retinal ganglion cells (mRGCs) constitute a system in the mammalian retina used for irradiance detection, regulating non-image forming functions, such as photoentrainment of circadian rhythms, control of the pupillary light reflex, masking response, light-regulated melatonin secretion, and modulation of the sleep/wake cycle. There are five subtypes of mRGCs differentiated by morphology and function. Recent years of research on mRGCs have identified a broad number of neurodegenerative diseases in the eye and the brain with altered physiologic light responses, leading to disturbances of non-image forming light response(s). In this review, we briefly summarise the melanopsin system in the normal retina and discuss its role in connection to human aging (sleep/wake problems) and retinal pathology in Alzheimer and Parkinson diseases, diabetic retinopathy, mitochondrial optic neuropathies, glaucoma, retinitis pigmentosa, and in photophobia during migraine and in seasonal affective disorder (SAD). Finally, we discuss the diagnostic tools that are being used to differentiate retinal diseases involving the melanopsin system in the rods and cones from the inner versus the outer retina.
Open Access
Neuronal A2A receptor exacerbates synapse loss and memory deficits in APP/PS1 mice.
(2024-08-01) Launay, Agathe; Carvalho, Kévin; Burgard, Anaëlle; Meriaux, Céline; Caillierez, Raphaëlle; Eddarkaoui, Sabiha; Kilinc, Devrim; Siedlecki-Wullich, Dolores; Besegher, Mélanie; Bégard, Séverine; Thiroux, Bryan; Jung, Matthieu; Nebie, Ouada; Wisztorski, Maxence; Déglon, Nicole; Montmasson, Claire; Bemelmans, Alexis-Pierre; Hamdane, Malika; Lebouvier, Thibaud; Vieau, Didier; Fournier, Isabelle; Buee, Luc; Lévi, Sabine; Lopes, Luisa V; Boutillier, Anne-Laurence; Faivre, Emilie; Blum, David; Gómez Murcia, Victoria; Farmacología
Early pathological upregulation of adenosine A2A receptors (A2ARs), one of the caffeine targets, by neurons is thought to be involved in the development of synaptic and memory deficits in Alzheimer's disease (AD) but mechanisms remain ill-defined. To tackle this question, we promoted a neuronal upregulation of A2AR in the hippocampus of APP/PS1 mice developing AD-like amyloidogenesis. Our findings revealed that the early upregulation of A2AR in the presence of an ongoing amyloid pathology exacerbates memory impairments of APP/PS1 mice. These behavioural changes were not linked to major change in the development of amyloid pathology but rather associated with increased phosphorylated tau at neuritic plaques. Moreover, proteomic and transcriptomic analyses coupled with quantitative immunofluorescence studies indicated that neuronal upregulation of the receptor promoted both neuronal and non-neuronal autonomous alterations, i.e. enhanced neuroinflammatory response but also loss of excitatory synapses and impaired neuronal mitochondrial function, presumably accounting for the detrimental effect on memory. Overall, our results provide compelling evidence that neuronal A2AR dysfunction, as seen in the brain of patients, contributes to amyloid-related pathogenesis and underscores the potential of A2AR as a relevant therapeutic target for mitigating cognitive impairments in this neurodegenerative disorder.
Open Access
Predictors of caregiver burden of patients with Alzheimer disease attending day-care centres
(MDPI, 2021-10-12) Gómez Gallego, Juan Cándido; Gómez Gallego, María; Economía Aplicada
Abstract: Nowadays, there are plenty of programs and resources to prevent caregiver burden of patients with Alzheimer’s disease. In spite of that, many caregivers suffer high levels of burden and stress, which leads to an earlier institutionalization of patients. This study aimed to explore the predictors of burden in relative caregivers of patients attending day-care centers and the moderating role of caregiver kinship in these associations. A sample of a hundred and two patient–caregiver dyads was recruited. Burden was measured with a Zarit Burden Interview. Measures of patients’ cognition, insight, depression, behavioral disturbances, functional ability and overall physical health were considered as predictors. We found that apathy, irritability and delusions and, patients’ mobility are the main determinants of caregivers’ burden. The strength of relationship between delusions and irritability was higher in spouse caregivers. Interventions to reduce burden should be adapted to the specific needs of a particular type caregiver.
Open Access
Prospects of induced pluripotent stem cells in treating advancing Alzheimer’s disease: A review
(Universidad de Murcia, Departamento de Biologia Celular e Histiologia, 2025) Park, Juyoun Janis; Rim, Yeri Alice; Sohn, Yeowon; Nam, Yoojun; Ju, Ji Hyeon
The World Health Organization has identified Alzheimer’s disease (AD), the leading cause of dementia globally, as a public health priority. However, the complex multifactorial pathology of AD means that its etiology remains incompletely understood. Despite being recognized a century ago, incomplete knowledge has hindered the development of effective treatments for AD. Recent scientific advancements, particularly in induced pluripotent stem cell (iPSC) technology, show great promise in elucidating the fundamental mechanisms of AD. iPSCs play a dual role in regenerating damaged cells for therapeutic purposes and creating disease models to understand AD pathology and aid in drug screening. Nevertheless, as an emerging field, iPSC technology requires further technological advancement to develop effective AD treatments in the future. Thus, this review summarizes recent advances in stem cell therapies, specifically iPSCs, aimed at understanding AD pathology and developing treatments
Open Access
Recuperación de la salud del cuidador principal, en proyecto sociocultural “Quisicuaba”. Los Sitios, Centro Habana.
(Murcia : Servicio de Publicaciones de la Universidad de Murcia, 2012) Martínez Cepero, Félix E.
La demencia causa discapacidad grave entre las personas que la padecen, provocando efectos diversos en las familias, y en la persona cuidadora, al extremo de experimentar estrés, frustración y total agotamiento. Comprobar la utilidad de un programa de recuperación de salud con un diseño descriptivo de corte transversal dentro del proyecto sociocultural “Quisicuaba, a través de una muestra de 26 cuidadores principales, permitió determinar características sociodemográficas y la persistencia de ansiedad, depresión y sobrecarga en estas personas, alteraciones posteriormente modificadas, luego de la intervención. Instrumentos diagnósticos como Inventario de ansiedad, escala de depresión de Hamilton, Cuestionario de Sobrecarga Zarit-Zarit, dinámicas grupales y entrevistas aportaron datos e interés, puesto que la tarea desarrollada permitió reconocer la creación de un espacio de respiro para estas personas, demostrando su utilidad con un mínimo de recursos y el apoyo de profesionales y aficionados del territorio. Solicitándose su generalización, a criterio de los participantes.

Browsing by Subject "Alzheimer’s disease"

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