(F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología, 2014) Márquez, Joana; Olaso, Elvira
Until recently, collagen interactions with
cells had been ascribed to integrins. The identification of
the Discoidin Domain Receptor (DDR) family as
collagen receptors represents a new paradigm in the
regulation of collagen-cell interactions. How DDR
signaling is biochemically linked to specific cell
regulatory functions remains largely unknown.
Moreover, the characteristic slow and substained
phosphorylation of DDRs and the elevated expression of
DDR2 in the myofibroblasts of healing wounds suggest
a role for DDR2 in physiological and pathological
wound healing. In fact, DDR2 signaling regulates cell
proliferation and extracellular matrix synthesis, which
are key aspects of fibroblast contribution to tissue
healing. In this review we summarize evidence in favor
of this concept.