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Open Access
Campus : Revista informativa y cultural de la Universidad de Murcia
(Vicerrectorado de Extensión Universitaria. Universidad de Murcia, 1985-10) Vera, Pascual; Martín, Ana María; Vera, Diego; Pozuelo Yvancos, José María
Pag. 2 Editorial Pag. 3 Los estatutos, obra de todos Pag. 4 Entrevista con el Rector Pag. 5 Estos son los miembros del Consejo Social Pag. 7 y 8 Información académica Pag. 9 Ciencia y tecnología Pag. 10 Paranorama de la poesía en Murcia. Pag. 11 Emmanuel Kant, personaje dramático. Marginalia Bueriana. Pag. 12 Alban Berg en su primer centenario Pag. 13 Sobre viejos conocidos en el principio de este otoño, II Semana de Cine Español. Pag. 14 Este verano Música en el escenario, Música en el escenario, Golpes Bajos, Graham Parker, Disco actualidad Pag. 15 Campeones, El nuevo pabellón, F.E.D.U., Miembros del C.U.M. al Kilimanjaro Pag. 16 ¡Viva la cultura viva! Bolsa del estudiante: Anuncios por palabras, Premios y concursos, Becas, Agenda Cultural
Open Access
Campus : Revista informativa y cultural de la Universidad de Murcia
(1985-11) Vera Nicolás, Pascual; Martín Luque, Ana María; Vera, Diego; Pozuelo Yvancos, José María
Pag. 2 Cartas al Director. Pag. 3 Tasas y financiación de la Universidad. Pag. 4 Los presupuestos de la Universidad. Pag. 5 Información académica. Pag. 7 Actividades Universitarias. Pag. 8 Ciencia y Tecnología Fisiología vegetal y economía en Murcia. Premios Nobel 1985. Pag. 9 Fernando Zóbel: el museo y la ciudad. Pag. 10 España en la música de Occidente. Pag. 11 Eca y Don Juan Almagro 85: Don Juan. Pag. 12 y 13 Paco Rabal en la cresta de la ola. Margarita Lozano: espléndida en la madurez. Tribulaciones de uan Semana de Cine. Cine en TV: vinieron las lluvias. Pag. 14 Cartago Music. Avatares del pop en Murcia. Pag. 15 Jornadas sobre Educación Física y Deportes. Comienzan los campeonatos y cursos. Tecnoquim-Club Universitario. Pag. 16 ¡Va por los artistas! La bolsa ocupacional en marcha. Agenda Cultural Campus.
Open Access
Campus : Revista informativa y cultural de la Universidad de Murcia
(1985-12) Vera Nicolás, Pascual; Martín Luque, Ana María; Vera, Diego; Pozuelo Yvancos, José María
Pag. 2 Cartas al director. Pag. 3 José Mª Aroca, Presidente del Consejo Social. Pag. 4 y 5 Mesa redonda sobre la vivienda. Pag. 7 Información académica. Pag. 8 Publicaciones. Pag. 9 Manipulaciones Genéticas y sus aplicaciones industriales. Franco Modigliani: Premio Nobel de Economía. Pag. 10 Tres homenajes en otoño. Pag. 11 Los conciertos de Pro Música. El trío en Si bemol, opus 8 de Brahms. Pag. 12 El realismo como vanguardia. El teatro actual de Martín Iniesta. Pag. 13 En Murcia. Cine en TVE: de superhombres, indios y bailes. Pag. 14 Julián Cope y su disco del hombre tortuga. Pag. 15 Kenya-Kilimanjaro '85. Pag. 16 Murcia y Nueva York. El seguro escolar. Agenda Cultural Campus.
Open Access
Problemas de identificación cultural de la segunda generación de emigrantes españoles (en Belgica): reflexión para una intervención
(Murcia : Área de Pedagogía Social, Universidad,, 1986) Porta Carrasco, Carmen; González Hernández, Ángel
Open Access
La guardia y custodia en los casos de separación y/o divorcio.
(Murcia : Área de Pedagogía Social, Universidad, 1986) Coy Ferrer, Antonio
Open Access
Observations on cell kinetics and viability of a human melanoma cell line exposed to dicarboxylic acids in tissue culture
(Murcia : F. Hernández, 1986) Breathnach, A. S.; Robins, E.J.; Bhasin, Y. P.; Ethridge, L. B.; Nazzaro-Porro, M.; Passi, S.; Picardo, M.
Cultures of human nlelanonla cell line BOO08 \verc e-iposed to the disodium salts of arelaic acid (C,, 2Na), adipic acid (C,, 2Na) and dodecanediaic acid (C,, 2Na) at IO'M and 5 x 10-'M for 24 hrs. None of the diacid salts had a significant effect on growth rate or viability of the cells, at 10-'M for 24 hrs nor had C, 2Na any effect at 5 x 10'M. At 5 x 102M for 24 hrs, both C,, 2Na, and CIL2 Na had a significant effect in reducing both growth and viability. These effects were accompanied by morphological evidence of cell death, and swelling of mitochondria and accuni~~latioonf lipid droplets within cytoplasm of still biable cells.
Open Access
Los talleres de tiempo libre en el trabajo con el menor.
(Murcia : Área de Pedagogía Social, Universidad, 1986) Aledo Romero, José; Cazorla Díaz, Juan Antonio
Open Access
Blastic OKT6-positive proliferation preceding malignant histiocytosis
(Murcia : F. Hernández, 1986) Bonetti, F.; Chilosi, M.; Menestrina, F.; Lestani, M.; Scarpa, A.; Todeschini, G.; Pizzolo, G.; Fioredonati, L
A 45-year old male presented latero-cervical lymphoadenopathy. Biopsy revealed a malignant proliferation of immature "lymphoid" cells bearing T6 antigen and HLA-DR but negative for other lymphoid markers, suggesting a phenotype similar to Langerhans cells. The patient did not receive any therapy and six months later developed a histologically typical malignant histiocytosis, involving spleen and liver. Other reported cases of lymphoid malignancies (two bearing the 7'6 antigen on blast cells) preceding malignant histiocytosis were found and compared with ours. Most of these cases were characterized by the pediatric age of the patients and were presented as acute leukemias exhibiting, in at least some of them, reliable T-cell markers. Our case appears to represent, on the other hand, a blastic proliferation of precursors of both histiocytes and Langerhans dendritic cells which eventually progressed to malignant histiocytosis. The relevance of this observation in the debate on the origin of Langerhans cells and the relationships existing between macrophages and dendritic cells is discussed.
Open Access
Substance P-like immunoreactivity in rat and cat carotid bodies, Light and electron microscopic studies
(Murcia : F. Hernández, 1986) I-li Chen; Yates, Robert D.; Hansen, John T.
Substance P-immunoreactive (SP-I) structures in the carotid bodies of rats and cats were examined with the light and electron microscopes. In both species SP-I varicose nerve fibers were located singly in the interstitial connective tissue in close association with blood vessels. They were small unmyelinated fibers enveloped in a common Schwann cell sheath with other SP-negative fibers. Some of SP-I fibers contained large dense-cored granules and small clear vesicles in addition to microtubules and mitochondria and probably represented nerve fiber varicosities. The latter often were found incompletely invested by Schwann cell sheaths. SP-fibers were found occasionally in the envelopes of supporting cells at the periphery of parenchymal cell groups. However, none of the nerve terminals making synaptic contacts with glomus cells exhibited SP-like immunoreactivity. In cat carotid bodies some glomus cells showed moderate to intense SPlike immunoreactivity.The intense SP-I glomus cells displayed numerous dense-cored vesicles of 85 to 140 nm in diameter and frequently showed synaptic contacts with SP-negative nerve terminals. In rat carotid bodies we were unable to detect consistent SP-immunoreactivity in glomus cells. Our results do not favor the hypothesis that SP is a neurotransmitter/modulator in the chemoreceptor afferents synapsing on glomus cells in either the cat or rat carotid body. However our results support the hypothesis that SP in cat glomus cells may play a role in the modulation of chemoreceptor activity.
Open Access
Perspectiva histórica y concepción actual de los internados.
(Murcia : Área de Pedagogía Social, Universidad, 1986) González Funes, Diego; Bohajar Nicolás, Enrique; Parra Ortega, José A.
Open Access
Duodenal microanatomy of the domestic cat. (Felis catus)
(Murcia : F. Hernández, 1986) Robert, Henry W.; Al-Bagdadi, F.K.
Duodenal samples were taken from similar locations in six cats, processed, stained, and examined via light microscope. There were no prominent circular folds (plicae circulares) or stratum compactum (lamina subglandularis). The 1072 pm X 201 pm villi were covered by 46 pm high columnar epitheliocytes proximally which decreased in height (41 pm) distally and displayed a 1.1 - 1.7 pm striated border. Globular leukocytes, mononuclear cells, and twenty-eight goblet cells (exocrinocytus calciformis) per villus were seen. The intestinal gland (crypt of Lieberkuhn) epithelium was 20 pm tall and had a less distinct striated border. The 515 pm simple straight tubular intestinal gland layer displayed distal branching. Many mitotic figures, 12 goblet cells per gland, and occasional columnar to triangular cells with red cytoplasmic granules were seen. The thickness of the lamina propria mucosa (glandular portion) decreased from proximal to distal (563-465 pm). The lamina muscularis mucosa had two layers and decreased in thickness distally (71-28 pm). The proximal muscularis mucosa was penetrated by the ducts of submucosal (Brunner's, duodenal) glands. The tela submucosa decreased in thickness distally (593-192 pm) and contained submucosal glands with 11.5 - 75 pm lumina for the first 1.5 - 2.5 cm. However, submucosal glands could be found to a distance of 8 cm. The glandular epithelium ranged from 7.5 - 22.5 pm in height. Only one type of secretory cell was observed, with both mucous and serous properties. The tunica muscularis ranged from 190-1425 pm (median thickness of 557 pm) and had two layers.
Open Access
Encephalopathy with astrocitic residual bodies. Report of a case and rewiev of the literature
(Murcia : F. Hernández, 1986) Figols, J.; Cervós-Navarro, J.; Wolman, M.
Biopsy and autopsy findings in a girl who died at 7% months after having suffered from progressive axial hypotonia, myoclonus, EEG changes and retarded psychomotor development. Inclusions consisting of lamellar profiles, situated in membrane-bound cytosomes were found mainly in astrocytes, but also in neurones and in axons of peripheral nerves. Lipofuscin bodies were also increased in number. The patient belongs in the same category as cases studied by Towfighi et al. (1975) and Martin et al. (1977). Etiology and pathogenesis of this syndrome remain unknown. It is suggested, however, that the pathological changes observed might have been caused by the administration soon after birth of anti-epileptic dmgs (diphenylhydantoin, clonazepam and nitrazepan).
Open Access
Occurrence of pancreatic ductal cell dysplasia in rats fed with a high fat diet and ethanol
(Murcia : F. Hernández, 1986) Jalovaara, P.; Rämö, J.; Apaja-Sarkkinen, M.
The effects of alcohol and diet on acute pancreatitis were studied in 192 male Wistar rats. The animals were fed with standard laboratory food up to three months of age and, after that, were divided into four groups of 48 animals,each group receiving a different diet: standard, fat-rich, protein-rich or carbohydrate-rich. In each diet group, 24 animals obtained 15% (v/v) ethanol in their drinking solution while the other 24 rats had water ad libitum. The diet period lasted for 12 weeks, after which acute experimental pancreatitis was induced under diethyl ether anesthesia by ductal injection of rat bile into the pancreatic ducts. Moderate or severe ductal cell dysplasia developed in three of the 15 survivors in the group fed with a high-fat diet and 15% ethanol in their drinking solution. Mild acute pancreatitis was histologically found in 13 rats and moderate pancreatitis in one rat in this group. One rat did not show any pancreatic parenchyma1 changes. Two of the rats with ductal cell dysplasia had mild pancreatitis and the pancreas of the third rat was normal in this respect. Dysplastic changes were not found in any other experimental group used in the study. The observation is statistically significant at p < 0.025 level. The results indicate that alcohol and a high fat diet together might have a carcinogenic effect on pancreatic ductal epithelium in rats.
Open Access
An autoradiographic study of the uptake of tritiated proline by osteoblasts during hibernation
(Murcia : F. Hernández, 1986) Steinberg, B.; Singh, I.J.; Mitchell, O.G.
Twenty-four LSH and LVG strain golden hamsters, Mesocricetus auratus, were used. Experimental animals were maintained at 5 C and allowed to hibernate. Control animals were kept at 27 C. Six animals (3 experimental, 3 control) were injected subcutaneously with I pCi of 'H-proline/gm body wt. (Spec. act. 3 Ci/mM) after hibernation lasting 12 hours, I day, 3 days, or 7 days. Animals were killed I hour after injection and autoradiographs were prepared from 5 Frn thick ilecalcified sections of femurs. A greater number of endosteal cells were labeled than periosteal cells and also exhibited a greater magnitude of labeling throughout the study. Differences between endosteal and periosteal cells both in percentage of cells labeled and magnitude of labeling were maximum in control animals and progressively decreased with increasing periods of hibernation. A reduction in synthesis of matrix proteins during the early period of hibernation was seen and was attributed to a significant reduction both in average cell activity and in the number of active cells during hibernation. The latter phenomenon apparently made a large contribution to the reduced matrical synthesis. 'H-proline uptake by osteoblasts probably retlects the reduced requirements of matrical synthesis during hibernation.
Open Access
Analisis de la motivación e integración que presentan niños gitanos en actividades de tiempo libre
(Murcia : Área de Pedagogía Social, Universidad, 1986) García Meseguer, Miguel; Aroca Arques, Antonio; Martínez Martínez, Carmen
Open Access
Further characterization of spontaneous arthritic changes in murine squamo-mandibular joint: histopathological aspects
(Murcia : F. Hernández, 1986) Livne, E.; Silbermann, M.
The appearance of age-related ulcerative changes in the mouse mandibular condyle were evaluated by light and electron microscopy examinations. Fibrillations appeared along the articular surface and in deeper tissue regions, as early as at six months of age. Such changes were characterized by a marked loss of the tissue's cellularity and by a marked reduction in matrix metachromasia and safranin-0 staining. These microscopical changes were accompanied by a reduced reactivity for both ruthenium red and colloidal iron binding, as noted ultrastructurally. At the same time, increasing numbers of erythrocytes appeared to be adhered to the surface irregularities and were also found in deeper regions within the articular lesions. Using morphological criteria, it became apparent that the degenerative changes of aging articular cartilage started at the more superficial regions of the tissue and only thereafter proceeded toward the chondro-osseous junction. Also, with the advancement of age, the degenerative changes became more severe
Open Access
Effects of mellitic acid (MA) and sodium fluoride (NaF) on the histological appearance of murine fetal tibiae cultured in vitro
(Murcia : F. Hernández, 1986) Weischer, C.H.; Krisinger, J.; Karzel, K.
The aim of this studv was to develop a standardized image analysis method for localization and quantitative measurement of calcified structures of murine fetal tibiae cultured in vitro as a completion and verification of previous biochemical studies. The calcified structures of bone stained by von Kossa silver technique and the epiphyseal cartilages showing intensive metachromasia with toluidine-blue staining were converted with grey-value window programs and afterwards the areas of the selected structures were measured. The histomorphological investigations showed that the murine tibiae, incubated for a period of 6 days in a medium with addition of 5 mmol mellitic acid, showed both a significant reduction of calcium deposits and an increase of epiphyseal intercellular cartilage matrix. The tibiae incubated in a medium with addition of 0.5 mmol sodium fluoride significantly showed an increase of calcium deposits in the thickened lammellae of the cornpacta. These histomorphological results confirm previous biochemical studies.
Open Access
Tareas y funciones de la pedagogía social
(Murcia : Área de Pedagogía Social, Universidad,, 1986) Volpi, Claudio
Open Access
A multihormonal tumor of the pancreas producing neurotensin associated with the WDHA syndrome. Histology, histochemistry and origin
(Murcia : F. Hernández, 1986) Bani-Sacchi, Tatiana; Bartolini, Giancarlo; Biliotti, Giancarlo
A pancreatic tumor associated with severe LVDHA syndrome has been studied histologically and immunohistochemically. Light microscopy revealed that the growth pattern of' the tunlor varied greatly from zone to zone but with prevailing solid arrangement of the tumoral cells. The majority of the endocrine cells showed numerous eosinophilic, PTAH-positive, and argyrophilic secretory granules, that were ultrastructurally similar to those of normal and tumoral neurotensin-containing cells. A minority of the endocrine cells had secretory granules ultrastructurally different from the aforementioned ones, but these were not diagnostic on purely morphological grounds. Inside the tumor, immunol~istochemistryd emonstrated a majority of neurotensin-immunoreactive cells, sparse and small clusters of VIP-immunoreactive cells and few, dispersed pancreatic polypeptide-immunoreactive cells. Some structural and ultrastructural aspects of the tumoral stroma have also been reported. Ducts and solid masses of duct-like cells were also found, and small clusters and singly dispersed duct-like cells were seen invading the endocrine tissue and undergoing mitoses. Such features suggest that the tumor originated from precursors located in the medium-sized and small pancreatic ducts. Because of the multihormonal nature of the tumor, the role of neurotensin and VIP in producing the patient's symptoms is discussed and a synergistic action of the two hormones is suggested in causing the particularly severe WDHA syndrome.
Open Access
The kinetic differences between sodium nitrite, amyl nitrite and nitroglycerin oxidation of hemoglobin
(Murcia : F. Hernández, 1986) Tarburton, John Philip; Metcalf, William K.
The effect of sodium nitrite, amyl nitrite and nitroglycerin (glyceryl trinitrate) on the hemoglobin of adult erythrocytes was examined in vitro. Both amyl nitrite and nitroglycerin reacted immediately with oxyhemoglobin to effect oxidation into methemoglobin while sodium nitrite required an inductionary period (lag phase) prior to the reaction. Kinetic studies of the biniolecular rate law for each of the preceeding reaction's reactionary periods (log phases) allowed rate constant calculations to be made. The values are 1.14 x 10JM niin I, 7.45 x IOJbl lmin I , and 3.50 x 10IM ' m i n 1 for sodium nitrite, amyl nitrite and nitroglycerin, respectic ely. A comparison of the amyl nitrite and nitroglycerin rate constants reveals that aniyl nitrite is approximately 2000-fold more toxic to oxyhemoglobin than nitroglycerin. These oxidant's effect on in !/itro hemoglobin solutions are comparable since both reactions approximate to rectangular hyperbolae. Sodium nitrite reacts about 300-fold faster with oxyhemoglobin than does nitroglycerin. However, the sodium nitrite reaction proceeds in a sigmoidal fashion which makes a strict comparison between these compounds relative toxicities less clear cut.