(F. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histología, 2013) Zalvide, Juan; Fidalgo, Miguel; Fraile, María; Guerrero, Ana; Iglesias, Cristina; Floridia, Ebel; Pombo, Celia M.
Specific mutations in the CCM3 gene
predispose to the development of cerebral cavernous
malformations, a special type of vascular lesions. This
calls for an elucidation of the precise nature of the
CCM3 protein and a deep understanding of its molecular
regulation. In this review, we outline our current
knowledge of the different CCM3 protein complexes.
We focus on the GCKIII family of kinases as partners of
CCM3 and discuss the functional consequences of this
partnership, putting forward a putative model for the
activation of these kinases.