Histology and histopathology Vol. 4, nº 1 (1989)

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Browsing Histology and histopathology Vol. 4, nº 1 (1989) by Author "Imai, Yutaka"

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    Endogenous sex hormone and estrogen binding activity in thyroid cancer
    (Murcia : F. Hernández, 1989) Imai, Yutaka; Yamakawa, Mitsunori; Matsuda, Mikio; Takeshi, Kasajima
    Summary. The reactions of four anti-sex hormone (Estrone, Estradiol, Estriol and Testosterone) antisera were immunohistochemically examined in 109 cancerous and 80 normal and benign thyroid tissues. Four kinds of sex hormones were detected in the tumour cells of 61 cases (56%) of thyroid cancer and in the follicular epithelial cells of 4 cases (5%) of normal and benign thyroid tissues. Among the thyroid cancers, 54 female (61%) and 7 cases in males (33%) were positive for sex hormones. Furthermore, estrogen binding activity was screened histochemically in 36 thyroid tissues of various types, and detected not only in thyroid cancer (6115 cases), but in normal and benign thyroid tissues (3121 cases) as well. It was concluded that endogenous estradiol was located in thyroid cancers more frequently in females than in males and that there was estrogen binding activity in the cells of not only thyroid cancers, but also normal and benign thyroid tissues. This is the first report of the dernonstration of endogenous sex hormones in thyroid cancer.
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    Ultrastructural localization of Cu, Zn-SOD in hepatocytes of patients with various liver diseases
    (Murcia : F. Hernández, 1989) Saito, Takafumi; Shinzawa, Haruhide; Togashi, Hitoshi; Wakabayashi, Hiroto; Ukai, Katsuaki; Takahashi, Tsuneo; Ishikawa, Makoto; Dobashi, Michio; Imai, Yutaka
    The ultrastructural localization of copper, zinc-superoxide dismutase (Cu, Zn-SOD) in the liver of patients with acute hepatitis, chronic hepatitis, liver cirrhosis and alcoholic fatty liver was studied by means of the indirect immunoperoxidase technique. In hepatocytes Cu, Zn-SOD was found to be localized in perinuclear cisternae, rough endoplasmic reticulum (rER), vesicles and Golgi apparatus. The Cu, Zn-SOD was also detected around the lipid droplets in hepatocytes as well as on the cytoplasmic membrane in cases of liver cirrhosis. These findings suggest that Cu, Zn-SOD is produced in the rER in hepatocytes and protects the cells from cellular injury caused by superoxide anion radical in various disorders of the liver.