(Murcia : F. Hernández, 2011-01-18) Carretero, J.; Sánchez, F.; Torres, J. L.; Blanco, E.; Riesco, J. M.; Vázquez, R.
The TSH-producing adenohypohyseal cells
of Wistar rats were studied after treatment with orally
administered methymazole by the PAP immunocytochemica1
method. These cells were compared with those of
normal animals. The effects of methymazole were
different in the females to those observed in males. In
both sexes. the numerical density (number of TSH cells
per 1000 pm2) increased after treatment. The cellular and
cytoplasmic areas increased in the females while they
decreased in the males. The nuclear area and the nuclear
area/cytoplasmic area ratio increased in the males and
decreased in the females following treatment with
methymazole. This treatment caused the appearance of
large. intensely stained cells, with an eccentric nucleus
and cytoplasmic processes accompanied by weakly
stained cells that were situated close to blood vessels.