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|Título:||Morphological changes induced by colchicine in the chick optic cup in early stages of development. A stereological study|
|Editor/es:||Murcia : F. Hernández|
|Publicado en:||Histology and histopathology|
|Materias relacionadas:||CDU::5 - Ciencias puras y naturales::57 - Biología::576 - Biología celular y subcelular. Citología|
|Resumen:||In this study chick embryo optic cups at HH stage 13 of development were analyzed under normal conditions and after inoculation with colchicine for 1, 2, 4, and 8 h. Several changes were seen after these periods of treatment: 1) modifications of the structure, with thicker regions in the cup and a general decrease in the total volume according to the duration of exposure to the drug (about 4 times less than normal, 5,035 x lo3 ym3 vs 1,334 x lo3 ym3 after 8 h of treatrnent); 2) enlargement of the ventricular cavity and its closure, due to failure of approximation of retina1 and pigmentary layers; 3) failure of lens development, with delay and impairment of pit formation and deformation of al1 structures; lens volume was less than normal (about 4 times less, 2,148 x 103 pm3 vs 658 x lo3 pm3. after 8 h of treatment); 4) a general segregation of the cells making up the structure, principally in the more active proliferating zones. The local alterations found are described|
|Autor/es principal/es:||Abadía Molina, F.|
Abadía Fenoll, F.
|Tipo de documento:||info:eu-repo/semantics/article|
|Número Páginas / Extensión:||8|
|Appears in Collections:||Vol. 8, nº 2 (1993)|
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